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that the novel anti-inflammatory cytokine interleukin- (IL-) 37 was expressed in the foam-like cells of atherosclerotic coronary and carotid artery plaques, suggesting that IL-37 is involved in atherosclerosis-related diseases. However, the plasma levels of IL-37 in patients with acute coronary syndrome (ACS, including unstable angina pectoris and acute myocardial infarction) have yet to be investigated.\n                    <jats:italic>Methods.<\/jats:italic>\n                    Plasma IL-37, IL-18, and IL-18BP levels were measured in 50 patients with stable angina pectoris (SAP), 75 patients with unstable angina pectoris (UAP), 67 patients with acute myocardial infarction (AMI), and 65 control patients.\n                    <jats:italic>Results.<\/jats:italic>\n                    The plasma IL-37, IL-18, and IL-18BP levels were significantly increased in ACS patients compared to SAP and control patients. A correlation analysis showed that the plasma biomarker levels were positively correlated with each other and with the levels of C-reactive protein (CRP),\n                    <jats:italic>N<\/jats:italic>\n                    -terminal probrain natriuretic peptide (NT-proBNP), and left ventricular end-diastolic dimension (LVEDD) but negatively correlated with left ventricular ejection fraction (LVEF). Furthermore, the plasma IL-37, IL-18, and IL-18BP had no correlation with the severity of the coronary artery stenosis.\n                    <jats:italic>Conclusions.<\/jats:italic>\n                    The results indicate that the plasma IL-37 levels are associated with the onset of ACS.\n                  <\/jats:p>","DOI":"10.1155\/2014\/165742","type":"journal-article","created":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T05:17:46Z","timestamp":1394342266000},"page":"1-9","source":"Crossref","is-referenced-by-count":79,"title":["Elevated Plasma IL-37, IL-18, and IL-18BP Concentrations in Patients with Acute Coronary Syndrome"],"prefix":"10.1155","volume":"2014","author":[{"given":"Qingwei","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China"},{"name":"Department of Cardiology, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 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