{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:55:07Z","timestamp":1776423307444,"version":"3.51.2"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Major International (Regional) Joint Research Project","award":["81120108021"],"award-info":[{"award-number":["81120108021"]}]},{"name":"Major International (Regional) Joint Research Project","award":["81273304"],"award-info":[{"award-number":["81273304"]}]},{"name":"Major International (Regional) Joint Research Project","award":["Cxzz12_0066"],"award-info":[{"award-number":["Cxzz12_0066"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81120108021"],"award-info":[{"award-number":["81120108021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273304"],"award-info":[{"award-number":["81273304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Cxzz12_0066"],"award-info":[{"award-number":["Cxzz12_0066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangsu Province Kejiao Xingwei Program","award":["81120108021"],"award-info":[{"award-number":["81120108021"]}]},{"name":"Jiangsu Province Kejiao Xingwei Program","award":["81273304"],"award-info":[{"award-number":["81273304"]}]},{"name":"Jiangsu Province Kejiao Xingwei Program","award":["Cxzz12_0066"],"award-info":[{"award-number":["Cxzz12_0066"]}]},{"name":"Jiangsu Province Graduate Innovation Project","award":["81120108021"],"award-info":[{"award-number":["81120108021"]}]},{"name":"Jiangsu Province Graduate Innovation Project","award":["81273304"],"award-info":[{"award-number":["81273304"]}]},{"name":"Jiangsu Province Graduate Innovation Project","award":["Cxzz12_0066"],"award-info":[{"award-number":["Cxzz12_0066"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Previous studies indicated that bone marrow mesenchymal stem cells (BMSCs) from patients with systemic lupus erythematosus (SLE) exhibited impaired capacities of proliferation, differentiation, and immune modulation. Considering that migration capacity is important for the exertion of BMSCs functions, the defects in migration might contribute to BMSCs dysfunction in SLE patients. In this study, we showed that the migration capacity of SLE BMSCs was remarkably impaired in comparison with those of healthy controls. Increased tumor necrosis factor<jats:italic>\u03b1<\/jats:italic>(TNF-<jats:italic>\u03b1<\/jats:italic>) in SLE serum significantly inhibited the migration capacity and<jats:italic>in vivo<\/jats:italic>homing capacity of SLE BMSCs via a specific TNF receptor I (TNFRI) manner, in which decreased HGF mRNA production caused by the activation of I kappa B kinase beta (IKK-<jats:italic>\u03b2<\/jats:italic>) pathway is partially involved. To our knowledge, this is the first report to discuss the possible mechanisms for impaired migration of BMSCs in SLE patients. Our results suggest that inhibition of TNF-<jats:italic>\u03b1<\/jats:italic>pathway might be helpful for accelerating BMSCs migration to the inflammatory microenvironment in SLE patients, thereby having a potential role in SLE treatment.<\/jats:p>","DOI":"10.1155\/2014\/169082","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T16:00:35Z","timestamp":1416844835000},"page":"1-14","source":"Crossref","is-referenced-by-count":26,"title":["Association of TNF-<i>\u03b1<\/i>with Impaired Migration Capacity of Mesenchymal Stem Cells in Patients with Systemic Lupus Erythematosus"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8983-2326","authenticated-orcid":true,"given":"Linyu","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-0668","authenticated-orcid":true,"given":"Dandan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2012.0417"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mt.6300192"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-013-2508-z"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1449"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172687"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-97602012000300008"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-051060"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2009.0365"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/292109"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0633-0"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.05.091"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-008-0378-3"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-475X.2009.00454.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/754802"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-009-1529-y"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4140\/TCP.n.2013.110"},{"issue":"1","key":"17","first-page":"5","volume":"1","year":"1998","journal-title":"International Journal of Molecular Medicine"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/art.27548"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1002\/stem.68"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3727\/096368911X582769"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2011.0447"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/826182"},{"issue":"9, article 1725","key":"23","volume":"40","year":"1997","journal-title":"Arthritis and Rheumatism"},{"issue":"4","key":"24","first-page":"657","volume":"20","year":"1993","journal-title":"The Journal of Rheumatology"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.074484"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22729"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.50"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-011-9317-y"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.08.026"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1016\/j.repc.2012.05.014"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/art.38189"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3181cc0913"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1279"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029007"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.13"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.12.3986-3994.2001"},{"issue":"1","key":"37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/(SICI)1097-4652(199807)176:1<127::AID-JCP15>3.0.CO;2-4","volume":"176","year":"1998","journal-title":"Journal of Cellular Physiology"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)01984-8"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2005.01.049"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200315994"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2008-0512"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-012-9364-9"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1080\/14653240903051541"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/169082.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/169082.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/169082.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T20:51:28Z","timestamp":1498164688000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2014\/169082\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":43,"alternative-id":["169082","169082"],"URL":"https:\/\/doi.org\/10.1155\/2014\/169082","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}