{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:17:52Z","timestamp":1791253072068,"version":"4.1.0"},"reference-count":92,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Charles University in Prague, Czech Republic","award":["PRVOUK-P26\/LF1\/4"],"award-info":[{"award-number":["PRVOUK-P26\/LF1\/4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Mitochondrial dysfunctions are supposed to be responsible for many neurodegenerative diseases dominating in Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), and Huntington\u2019s disease (HD). A growing body of evidence suggests that defects in mitochondrial metabolism and particularly of electron transport chain may play a role in pathogenesis of AD. Structurally and functionally damaged mitochondria do not produce sufficient ATP and are more prominent in producing proapoptotic factors and reactive oxygen species (ROS), and this can be an early stage of several mitochondrial disorders, including neurodegenerative diseases. Mitochondrial dysfunctions may be caused by both mutations in mitochondrial or nuclear DNA that code mitochondrial components and by environmental causes. In the following review, common aspects of mitochondrial impairment concerned about neurodegenerative diseases are summarized including ROS production, impaired mitochondrial dynamics, and apoptosis. Also, damaged function of electron transport chain complexes and interactions between pathological proteins and mitochondria are described for AD particularly and marginally for PD and HD.<\/jats:p>","DOI":"10.1155\/2014\/175062","type":"journal-article","created":{"date-parts":[[2014,5,12]],"date-time":"2014-05-12T17:01:28Z","timestamp":1399914088000},"page":"1-9","source":"Crossref","is-referenced-by-count":251,"title":["Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer\u2019s Disease"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5448-1717","authenticated-orcid":true,"given":"Jana","family":"Hroudov\u00e1","sequence":"first","affiliation":[{"name":"Department of Psychiatry, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Ke Karlovu 11, 120 00 Prague 2, Czech 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