{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:32:20Z","timestamp":1778113940342,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T00:00:00Z","timestamp":1389484800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Physta is a proprietary product containing a freeze\u2010dried water extract of <jats:italic>Eurycoma longifolia<\/jats:italic> (tongkat ali), which is traditionally used as an energy enhancer and aphrodisiac. We aim to evaluate a 300\u2009mg combination of Physta and <jats:italic>Polygonum minus<\/jats:italic>, an antioxidant, with regard to sexual performance and well\u2010being in men. <jats:italic>Methods<\/jats:italic>. Men that aged 40\u201365 years were screened for this 12\u2010week randomized, double\u2010blind, placebo\u2010controlled, parallel\u2010group study. Outcome measures included validated questionnaires that aimed to evaluate erectile function, satisfaction with intervention, sexual intercourse performance, erectile hardness, mood, and overall quality of life. <jats:italic>Results<\/jats:italic>. 12 subjects in the active group and 14 in the placebo group completed the study. Significant improvements were noted in scores for the Sexual Intercourse Attempt diary, Erection Hardness Scale, Sexual Health Inventory of Men, and Aging Male Symptom scale (<jats:italic>P<\/jats:italic> &lt; 0.05 for all). Three adverse events were reported in the active group and four in the placebo group, none of which were attributed to study product. Laboratory evaluations, including liver and kidney function testing, showed no clinically significant abnormality. <jats:italic>Conclusion<\/jats:italic>. Supplementation for twelve weeks with <jats:italic>Polygonum minus<\/jats:italic> and the proprietary <jats:italic>Eurycoma longifolia<\/jats:italic> extract, Physta, was well tolerated and more effective than placebo in enhancing sexual performance in healthy volunteers.<\/jats:p>","DOI":"10.1155\/2014\/179529","type":"journal-article","created":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T21:01:24Z","timestamp":1389560484000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effects of a Proprietary Freeze\u2010Dried Water Extract of <i>Eurycoma longifolia<\/i> (Physta) and <i>Polygonum minus<\/i> on Sexual Performance and Well\u2010Being in Men: A Randomized, Double\u2010Blind, Placebo\u2010Controlled Study"],"prefix":"10.1155","volume":"2014","author":[{"given":"Jay K.","family":"Udani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie A.","family":"George","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mufiza","family":"Musthapa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"Pakdaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azreena","family":"Abas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,1,12]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.08.020"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.5534\/wjmh.2013.31.2.126"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2010.09986.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000175839"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijir.3901095"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-2918(01)80138-7"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2007.00600.x"},{"key":"e_1_2_9_8_2","first-page":"40","article-title":"Traditional herbal remedies used in the management of sexual impotence and erectile dysfunction in western Uganda","volume":"5","author":"Kamatenesi-Mugisha M.","year":"2005","journal-title":"African Health Sciences"},{"key":"e_1_2_9_9_2","first-page":"3","article-title":"Recent studies on aphrodisiac herbs for the management of male sexual dysfunction\u2014a review","volume":"68","author":"Malviya N.","year":"2011","journal-title":"Acta Poloniae Pharmaceutica"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X04001837"},{"key":"e_1_2_9_11_2","first-page":"103","article-title":"A summary of reported chemical constituents and medicinal uses of Eurycoma longifolia","volume":"8","author":"Hussein S.","year":"2007","journal-title":"Journal of Tropical Medicinal Plants"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.4066\/amj.2009.71"},{"key":"e_1_2_9_13_2","first-page":"479","article-title":"A gel-based proteomic kit to screen the quality of water-soluble root extracts of Eurycoma longifolia","volume":"17","author":"Doustjalali S. 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