{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:41:22Z","timestamp":1787632882006,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Membranous nephropathy (MN) is a common cause of nephrotic syndrome. In most cases it is idiopathic, while it may also be secondary to many diseases. In this study, prevalence of<jats:italic>H. pylori<\/jats:italic>infection and the effects of<jats:italic>H. pylori<\/jats:italic>eradication on proteinuria levels were investigated.<jats:italic>Methods<\/jats:italic>. Thirty five patients with MN (19 male), 12 patients with IgA nephropathy (4 male) and 12 patients with focal segmental glomerulosclerosis (FSGS) (8 male) were studied. The presence of<jats:italic>H. pylori<\/jats:italic>antigen was investigated in renal tissues obtained by biopsy, and the effects of<jats:italic>H. pylori<\/jats:italic>eradication on proteinuria levels were investigated.<jats:italic>Results<\/jats:italic>. Immunohistochemistry with<jats:italic>H. pylori<\/jats:italic>antigen revealed no positive staining in the glomeruli of all patients. 19 patients (54%) with MN, 10 (83%) with IgA nephropathy and 4 (33%) with FSGS were positive for<jats:italic>H. pylori<\/jats:italic>stool antigen test<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.045<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>. Patients with<jats:italic>H. pylori<\/jats:italic>infection were administered eradication therapy (lansoprazole, 30\u2009mg twice daily, plus amoxicillin, 0.75\u2009g twice daily, plus clarithromycin, 250\u2009mg twice daily, for 14 days). Before the eradication therapy the mean proteinuria of patients with MN, IgA nephropathy and FSGS were 2.42\u2009\u00b1\u20093.24\u2009g\/day, 2.12\u2009\u00b1\u20091.63\u2009g\/day and 1.80\u2009\u00b1\u20091.32\u2009g\/day, respectively. Three months after eradication, baseline proteinuria levels of patients with MN significantly decreased to 1.26\u2009\u00b1\u20091.73\u2009g\/day<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.031<\/mml:mn><\/mml:mrow><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:mrow><\/mml:math>. In all three groups there were no significant differences with regard to serum creatinine, albumin and C-reactive protein levels before and after eradication therapy.<jats:italic>Conclusions<\/jats:italic>. The eradication of<jats:italic>H. pylori<\/jats:italic>infection may be effective to reduce proteinuria in patients with MN, while spontaneous remission of MN could not be excluded in this patient cohort. This trial is registered with<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/clinicaltrials.gov\/ct2\/results?term=NCT00983034\">NCT00983034<\/jats:ext-link>.<\/jats:p>","DOI":"10.1155\/2014\/180690","type":"journal-article","created":{"date-parts":[[2014,2,24]],"date-time":"2014-02-24T21:01:46Z","timestamp":1393275706000},"page":"1-6","source":"Crossref","is-referenced-by-count":7,"title":["The Effects of<i>Helicobacter pylori<\/i>Eradication on Proteinuria in Patients with Primary Glomerulonephritis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Bahar","family":"Caliskan","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2526-3483","authenticated-orcid":true,"given":"Halil","family":"Yazici","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Millet Caddesi, Capa, 34093 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasar","family":"Caliskan","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Millet Caddesi, Capa, 34093 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasemin","family":"Ozluk","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Gulluoglu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isin","family":"Kilicaslan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aydin","family":"Turkmen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Millet Caddesi, Capa, 34093 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Sukru","family":"Sever","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, 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