{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:13:41Z","timestamp":1787872421588,"version":"build-2784847793"},"reference-count":22,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic>In this study, we investigated the protective effect and mechanism of curcumin on a rat model of intestinal ischemia\/reperfusion (I\/R), which induces an acute liver lesion.<jats:italic>Methods.<\/jats:italic>Curcumin was injected into rats in the curcumin groups through left femoral vein. The same volume of vehicle (0.9% normal saline) was injected into sham and I\/R groups. Blood and liver tissue were gathered for serological and histopathological determination.<jats:italic>Results.<\/jats:italic>Intestinal I\/R led to severe liver injury manifested as a significant increase in serum AST and ALT levels; all of those were reduced by treatment with curcumin. Simultaneously, the activity of SOD in liver decreased after intestinal I\/R, which was increased by curcumin treatment. On the other hand, curcumin reduced MPO activity of liver tissue, as well as serum IL-6 and TNF-<jats:italic>\u03b1<\/jats:italic>levels observably. This is in parallel with the decreased level of liver intercellular cell adhesion molecule-1 (ICAM-1) and nuclear factor-<jats:italic>\u03ba<\/jats:italic>B (NF-<jats:italic>\u03ba<\/jats:italic>B) expression.<jats:italic>Conclusion.<\/jats:italic>Our findings suggest that curcumin treatment attenuates liver lesion induced by intestinal I\/R, attributable to the antioxidative and anti-inflammatory effect via inhibition of the NF-<jats:italic>\u03ba<\/jats:italic>B pathway.<\/jats:p>","DOI":"10.1155\/2014\/191624","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T21:11:37Z","timestamp":1408569097000},"page":"1-8","source":"Crossref","is-referenced-by-count":30,"title":["The Protective Effects of Curcumin on Experimental Acute Liver Lesion Induced by Intestinal Ischemia-Reperfusion through Inhibiting the Pathway of NF-<i>\u03ba<\/i>B in a Rat 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