{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:56:52Z","timestamp":1790621812070,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The diagnostic performance of positron emission tomography using<jats:sup>18<\/jats:sup>F-fluorodeoxyglucose (FDG-PET) in detecting nodal involvement in patients with anal canal cancer (ACC) has been investigated by several studies with conflicting results. The aim of our study is to systematically review and meta-analyze published data about this topic.<jats:italic>Methods<\/jats:italic>. A comprehensive computer literature search of PubMed\/MEDLINE, Scopus, and Embase databases was carried out on July 10 to find relevant articles concerning the diagnostic performance of FDG-PET in detecting locoregional nodal involvement in patients with ACC. No language restriction was used. Pooled diagnostic performance on a lesion-based analysis was calculated.<jats:italic>Results<\/jats:italic>. Seven retrospective and five prospective studies have been reviewed. Six studies allowed assessing pooled sensitivity; five studies allowed assessing pooled specificity. Sensitivity and specificity values of FDG-PET\/CT on a lesion-based analysis ranged from 31 to 100% and from 53 to 98%, with pooled estimates of 56% (95% CI: 45\u201367%) and 90% (95% CI: 86\u201393%), respectively.<jats:italic>Conclusions<\/jats:italic>. Our meta-analysis demonstrates that FDG-PET is a specific diagnostic tool in detecting locoregional lymph node involvement in patients with ACC. Low sensitivity is a major concern; however, higher sensitivity could be reached combining FDG-PET with MR scan.<\/jats:p>","DOI":"10.1155\/2014\/196068","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T16:01:36Z","timestamp":1391529696000},"page":"1-11","source":"Crossref","is-referenced-by-count":37,"title":["Diagnostic Performance of Positron Emission Tomography\/Computed Tomography Using Fluorine-18 Fluorodeoxyglucose in Detecting Locoregional Nodal Involvement in Patients with Anal Canal Cancer: A Systematic Review and Meta-Analysis"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1047-3333","authenticated-orcid":true,"given":"Carmelo","family":"Caldarella","sequence":"first","affiliation":[{"name":"Institute of Nuclear Medicine, Department of Radiological Sciences, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"},{"name":"Institute of Nuclear Medicine, Department of Bioimaging and Radiological 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