{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:14:20Z","timestamp":1774437260809,"version":"3.50.1"},"reference-count":36,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Fondo de Investigaci\u00f3n en Salud","award":["FIS\/IMSS\/PROT\/502"],"award-info":[{"award-number":["FIS\/IMSS\/PROT\/502"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Determination of anti-citrullinated peptide antibodies (ACPA) plays a relevant role in the diagnosis of rheumatoid arthritis (RA). To date, it is still unclear if the use of several tests for these autoantibodies in the same patient offers additional value as compared to performing only one test. Therefore, we evaluated the performance of using two assays for ACPA: second-generation anti-citrullinated cyclic peptides antibodies (anti-CCP2) and anti-mutated citrullinated vimentin (anti-MCV) antibodies for the diagnosis of RA. We compared three groups: RA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>142<\/mml:mn><\/mml:math>), chronic inflammatory disease (CIRD,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>86<\/mml:mn><\/mml:math>), and clinically healthy subjects (CHS,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>56<\/mml:mn><\/mml:math>) to evaluate sensitivity, specificity, predictive values, and likelihood ratios (LR) of these two assays for the presence of RA. A lower frequency of positivity for anti-CCP2 was found in RA (66.2%) as compared with anti-MCV (81.0%). When comparing RA versus other CIRD, sensitivity increased when both assays were performed. This strategy of testing both assays had high specificity and LR+. We conclude that adding the assay of anti-MCV antibodies to the determination of anti-CCP2 increases the sensitivity for detecting seropositive RA. Therefore, we propose the use of both assays in the initial screening of RA in longitudinal studies, including early onset of undifferentiated arthritis.<\/jats:p>","DOI":"10.1155\/2014\/198198","type":"journal-article","created":{"date-parts":[[2014,6,16]],"date-time":"2014-06-16T21:30:00Z","timestamp":1402954200000},"page":"1-6","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of Two Assays to Determine Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis in relation to Other Chronic Inflammatory Rheumatic Diseases: Assaying Anti-Modified Citrullinated Vimentin Antibodies Adds Value to Second-Generation Anti-Citrullinated Cyclic Peptides Testing"],"prefix":"10.1155","volume":"2014","author":[{"given":"Miriam Lizette","family":"D\u00edaz-Toscano","sequence":"first","affiliation":[{"name":"Programas de Doctorado en Farmacolog\u00eda y en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, JAL, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Maria","family":"Olivas-Flores","sequence":"additional","affiliation":[{"name":"Hospital General Regional 180 IMSS Tlajomulco, JAL, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya Amali","family":"Zavaleta-Mu\u00f1iz","sequence":"additional","affiliation":[{"name":"Programas de Doctorado en Farmacolog\u00eda y en Ciencias Biom\u00e9dicas, Centro Universitario de Ciencias de la Salud (CUCS), Universidad de Guadalajara, Guadalajara, JAL, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge Ivan","family":"Gamez-Nava","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n en Epidemiolog\u00eda Cl\u00ednica y Divisi\u00f3n de Investigaci\u00f3n en Salud, UMAE, Hospital de Especialidades (HE), Centro M\u00e9dico Nacional de Occidente (CMNO), IMSS, Guadalajara, JAL, Mexico"},{"name":"Programa de Doctorado en Salud P\u00fabica CUCS, 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