{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:08:39Z","timestamp":1792656519478,"version":"4.5.0"},"reference-count":204,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    For more than half a century, cytotoxic agents have been investigated as a possible treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues and cell cultures, both normal and tumoral. Snake venoms show the highest cytotoxic potential, since ophidian accidents cause a large amount of tissue damage, suggesting a promising utilization of these venoms or their components as antitumoral agents. Over the last few years, we have studied the effects of snake venoms and their isolated enzymes on tumor cell cultures. Some\n                    <jats:italic>in vivo<\/jats:italic>\n                    assays showed antineoplastic activity against induced tumors in mice. In human beings, both the crude venom and isolated enzymes revealed antitumor activities in preliminary assays, with measurable clinical responses in the advanced treatment phase. These enzymes include metalloproteases (MP), disintegrins, L-amino acid oxidases (LAAOs), C-type lectins, and phospholipases A\n                    <jats:sub>2<\/jats:sub>\n                    (PLA\n                    <jats:sub>2<\/jats:sub>\n                    s). Their mechanisms of action include direct toxic action (PLA\n                    <jats:sub>2<\/jats:sub>\n                    s), free radical generation (LAAOs), apoptosis induction (PLA\n                    <jats:sub>2<\/jats:sub>\n                    s, MP, and LAAOs), and antiangiogenesis (disintegrins and lectins). Higher cytotoxic and cytostatic activities upon tumor cells than normal cells suggest the possibility for clinical applications. Further studies should be conducted to ensure the efficacy and safety of different snake venom compounds for cancer drug development.\n                  <\/jats:p>","DOI":"10.1155\/2014\/203639","type":"journal-article","created":{"date-parts":[[2014,2,13]],"date-time":"2014-02-13T16:02:45Z","timestamp":1392307365000},"page":"1-19","source":"Crossref","is-referenced-by-count":156,"title":["Antitumoral Activity of Snake Venom Proteins: New Trends in Cancer Therapy"],"prefix":"10.1155","volume":"2014","author":[{"given":"Leonardo A.","family":"Calderon","sequence":"first","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana C.","family":"Sobrinho","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayena D.","family":"Zaqueo","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"de Moura","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy N.","family":"Grabner","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maur\u00edcio V.","family":"Mazzi","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Herm\u00ednio Ometto, UNIARARAS, N\u00facleo de Ci\u00eancias da Sa\u00fade-NUCISA, 13607-339 Araras, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Marcussi","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Universidade Federal de Lavras, UFLA, 37200-000 Lavras, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8645-7954","authenticated-orcid":true,"given":"Auro","family":"Nomizo","sequence":"additional","affiliation":[{"name":"Departamento de An\u00e1lises Cl\u00ednicas, Toxicol\u00f3gicas e Bromatol\u00f3gicas, Faculdade de Ci\u00eancias Farmac\u00eauticas de Ribeir\u00e3o Preto, Universidade de S\u00e3o Paulo, USP, Ribeir\u00e3o Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla F. C.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana P.","family":"Zuliani","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna M. A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Biotecnologia e Engenharia de Bioprocessos, Universidade Federal de S\u00e3o Jo\u00e3o del Rei, UFSJ, Campus Alto paraopeba, Ouro Branco, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saulo L.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica, Biotecnologia e Engenharia de Bioprocessos, Universidade Federal de S\u00e3o Jo\u00e3o del Rei, UFSJ, Campus Alto paraopeba, Ouro Branco, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo G.","family":"St\u00e1beli","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreimar M.","family":"Soares","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Biomol\u00e9culas Aplicadas \u00e0 Sa\u00fade, CEBio, Funda\u00e7\u00e3o Oswaldo Cruz, Fiocruz Rond\u00f4nia e Departamento de Medicina, Universidade Federal de Rond\u00f4nia, UNIR, Porto Velho, RO, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00540-013-1615-7","volume":"27","year":"2013","journal-title":"Journal of Anesthesia"},{"key":"3","first-page":"1133","volume":"132","year":"2013","journal-title":"Journal of Cancer"},{"key":"4","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1177\/03008916000863S109","volume":"86","year":"2000","journal-title":"Tumori"},{"key":"5","first-page":"1","volume":"121","year":"2008","journal-title":"Journal of Cell Science"},{"key":"6","first-page":"117","volume":"153","year":"2013","journal-title":"Cell"},{"issue":"6127","key":"7","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1126\/science.1234139","volume":"339","year":"2013","journal-title":"Science"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.2174\/138955706777934955"},{"key":"9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.addr.2012.09.033","volume":"64","year":"2012","journal-title":"Advanced Drug Delivery Reviews"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1002\/med.20070"},{"key":"11","volume-title":"Chemotherapy","year":"2000"},{"key":"12","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.2174\/138920112800784835","volume":"13","year":"2012","journal-title":"Current Pharmaceutical Biotechnologyp"},{"issue":"10","key":"13","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd1197","volume":"2","year":"2003","journal-title":"Nature Reviews Drug Discovery"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.5772\/52380"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2007.05.001"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2009.09.004"},{"issue":"5","key":"17","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1172\/JCI6915","volume":"104","year":"1999","journal-title":"The Journal of Clinical Investigation"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1586\/epr.09.45"},{"key":"19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11060-011-0763-6","volume":"107","year":"2012","journal-title":"Journal of Neuro-Oncology"},{"key":"20","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.2174\/156802612802652457","volume":"12","year":"2012","journal-title":"Current Topics in Medicinal Chemistry"},{"issue":"3","key":"21","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/08998280.2006.11928181","volume":"19","year":"2006","journal-title":"Proceedings (Baylor University. Medical Center)"},{"key":"22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.toxicon.2013.03.018","volume":"69","year":"2013","journal-title":"Toxicon"},{"issue":"2","key":"23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S2221-1691(13)60042-8","volume":"3","year":"2013","journal-title":"Asian Pacific Journal Tropical of Biomedicine"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2011.03.017"},{"issue":"36","key":"25","doi-asserted-by":"crossref","first-page":"6150","DOI":"10.2174\/0929867311209066150","volume":"19","year":"2012","journal-title":"Current Medicinal Chemistry"},{"key":"26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/psc.2463","volume":"19","year":"2013","journal-title":"Journal of Peptide Science"},{"issue":"7","key":"27","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.3851\/IMP2291","volume":"17","year":"2012","journal-title":"Antiviral Therapy"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2011.05.021"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-007-0653-1"},{"issue":"12","key":"30","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.3390\/toxins4121500","volume":"4","year":"2012","journal-title":"Toxins"},{"key":"31","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.biochi.2012.09.019","volume":"95","year":"2013","journal-title":"Biochimie"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1002\/jms.1242"},{"issue":"10","key":"33","first-page":"3584","volume":"36","year":"1976","journal-title":"Cancer Research"},{"issue":"8","key":"34","first-page":"1197","volume":"64","year":"1976","journal-title":"Indian Journal of Medical Research"},{"issue":"6","key":"35","first-page":"707","volume":"14","year":"1978","journal-title":"European Journal of Cancer and Clinical Oncology"},{"issue":"2","key":"36","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0014-5793(85)80132-0","volume":"192","year":"1985","journal-title":"FEBS Letters"},{"issue":"16","key":"37","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/0024-3205(87)90126-3","volume":"40","year":"1987","journal-title":"Life Sciences"},{"issue":"5","key":"38","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/jps.2600690532","volume":"69","year":"1980","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(82)90352-3"},{"issue":"1\u20133","key":"40","first-page":"139","volume":"5","year":"1992","journal-title":"FEMS Microbiology Immunology"},{"issue":"18","key":"41","first-page":"4993","volume":"54","year":"1994","journal-title":"Cancer Research"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.01.001"},{"issue":"2","key":"43","first-page":"71","volume":"55","year":"2005","journal-title":"Journal of the Pakistan Medical Association"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(90)90118-J"},{"issue":"5","key":"45","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0171-2985(97)80078-2","volume":"197","year":"1997","journal-title":"Immunobiology"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1191\/096032799678839716"},{"issue":"3","key":"47","first-page":"415","volume":"24","year":"1991","journal-title":"Biochemistry International"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(92)90058-D"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041892"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.1080\/09629350410001664770"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2006.04.008"},{"issue":"2","key":"52","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3181\/00379727-195-43129B","volume":"195","year":"1990","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"issue":"4","key":"53","first-page":"289","volume":"31","year":"1994","journal-title":"Seminars in Hematology"},{"key":"54","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.toxicon.2005.01.013","volume":"45","year":"2005","journal-title":"Toxicon"},{"issue":"7","key":"55","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1073\/pnas.87.7.2471","volume":"87","year":"1990","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"56","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010124"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(90)90132-H"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1080\/0962935029000041"},{"issue":"10","key":"59","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1590\/S0100-879X2005001000005","volume":"38","year":"2005","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2008.12.004"},{"key":"61","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(02)00102-2"},{"issue":"4","key":"62","first-page":"937","volume":"19","year":"1989","journal-title":"Biochemistry International"},{"key":"63","doi-asserted-by":"publisher","DOI":"10.1016\/0020-711X(92)90105-A"},{"key":"64","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1401"},{"key":"65","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.14.9539"},{"issue":"9","key":"66","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1248\/bpb.21.924","volume":"21","year":"1998","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"67","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1287"},{"key":"68","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.2130"},{"key":"69","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-305X(02)00140-4"},{"key":"70","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(01)00232-X"},{"key":"71","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0996"},{"key":"72","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2004.03.049"},{"key":"73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.06.025"},{"issue":"8","key":"74","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/jbt.21422","volume":"26","year":"2012","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"key":"75","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1021\/bi992416z","volume":"39","year":"2000","journal-title":"Biochemistry"},{"key":"76","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.08.044"},{"key":"77","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2006.01.021"},{"key":"78","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1993.1023"},{"key":"79","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(97)00024-1"},{"key":"80","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00126-3"},{"key":"81","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0208"},{"issue":"8","key":"82","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.4049\/jimmunol.160.8.4042","volume":"160","year":"1998","journal-title":"Journal of Immunology"},{"key":"83","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2005.04.020"},{"key":"84","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.4175"},{"key":"85","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2008.00229.x"},{"key":"86","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200936200"},{"key":"87","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-2333(03)00010-9"},{"issue":"15","key":"88","first-page":"3754","volume":"59","year":"1999","journal-title":"Cancer Research"},{"issue":"4","key":"89","first-page":"1033","volume":"8","year":"2002","journal-title":"Clinical Cancer Research"},{"issue":"10","key":"90","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.7314\/APJCP.2012.13.10.4855","volume":"13","year":"2012","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"91","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(95)00085-Z"},{"key":"92","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2003.11.004"},{"key":"93","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2003.11.006"},{"key":"94","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.04.021"},{"key":"95","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605007"},{"key":"96","doi-asserted-by":"publisher","DOI":"10.1021\/mp900232a"},{"key":"97","doi-asserted-by":"publisher","DOI":"10.1023\/B:JOPC.0000027852.92208.60"},{"key":"98","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2006.11.007"},{"key":"99","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.08.038"},{"key":"100","first-page":"42","volume":"2","year":"2011","journal-title":"Journal of Venom Research"},{"key":"101","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2009.01.003"},{"key":"102","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2009.137"},{"key":"103","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2009.03.007"},{"issue":"22","key":"104","doi-asserted-by":"crossref","first-page":"13289","DOI":"10.1016\/S0021-9258(18)51627-6","volume":"264","year":"1989","journal-title":"The Journal of Biological Chemistry"},{"issue":"1","key":"105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3109\/08923979809034806","volume":"20","year":"1998","journal-title":"Immunopharmacology and Immunotoxicology"},{"key":"106","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(96)00097-4"},{"issue":"1","key":"107","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00873905","volume":"11","year":"1993","journal-title":"Investigational New Drugs"},{"key":"108","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2478(00)00293-5"},{"key":"109","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(01)01177-6"},{"key":"110","doi-asserted-by":"publisher","DOI":"10.1016\/j.biologicals.2009.01.010"},{"key":"111","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(98)00188-3"},{"key":"112","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1999.1511"},{"issue":"5","key":"113","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0041-0101(87)90290-X","volume":"25","year":"1987","journal-title":"Toxicon"},{"issue":"12","key":"114","first-page":"1474","volume":"24","year":"2005","journal-title":"Ai Zheng"},{"issue":"4 a","key":"115","first-page":"1719","volume":"16","year":"1996","journal-title":"Anticancer Research"},{"key":"116","first-page":"4023","volume":"19","year":"1999","journal-title":"Anticancer Research B"},{"key":"117","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(01)00106-4"},{"issue":"3\u20136","key":"118","first-page":"177","volume":"31","year":"2001","journal-title":"Haemostasis"},{"key":"119","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2007.01.001"},{"key":"120","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2012.03.002"},{"key":"121","doi-asserted-by":"publisher","DOI":"10.1016\/0041-0101(96)00017-7"},{"key":"122","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(00)00259-0"},{"key":"123","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-9861(03)00385-0"},{"key":"124","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(96)00108-0"},{"key":"125","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4838(99)00268-X"},{"key":"126","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01163-9"},{"issue":"2","key":"127","first-page":"377","volume":"50","year":"2002","journal-title":"Revista de Biologia Tropical"},{"issue":"7","key":"128","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1590\/S0100-879X1998000700001","volume":"31","year":"1998","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"129","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(94)90049-3"},{"key":"130","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03233.x"},{"key":"131","volume-title":"Snake venom peptides: promising molecules with anti-tumor effects","year":"2013"},{"key":"132","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(99)00187-7"},{"key":"133","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4165(96)00140-7"},{"key":"134","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.51.32599"},{"key":"135","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(01)00216-X"},{"key":"136","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0041-0101(01)00275-6","volume":"40","year":"2002","journal-title":"Toxicon"},{"issue":"7","key":"137","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.2460\/ajvr.1987.48.07.1063","volume":"48","year":"1987","journal-title":"American Journal of Veterinary Research"},{"key":"138","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00094-0"},{"key":"139","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02506-6"},{"key":"140","doi-asserted-by":"publisher","DOI":"10.1023\/B:HREV.0000011395.11179.af"},{"key":"141","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(99)00302-9"},{"key":"142","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(99)01926-5"},{"key":"143","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(00)00061-3"},{"key":"144","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200086200"},{"key":"145","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(91)80615-A"},{"key":"146","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(97)00131-X"},{"key":"147","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1996.9787"},{"key":"148","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.2129"},{"key":"149","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2003.10.008"},{"issue":"2","key":"150","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3181\/00379727-195-43129B","volume":"195","year":"1990","journal-title":"Proceedings of the Society for Experimental Biology and Medicine"},{"issue":"4","key":"151","first-page":"289","volume":"31","year":"1994","journal-title":"Seminars in Hematology"},{"key":"154","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2008.11.022"},{"issue":"4","key":"153","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1055\/s-2007-1003568","volume":"12","year":"1986","journal-title":"Seminars in Thrombosis and Hemostasis"},{"key":"155","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2112606"},{"issue":"7","key":"156","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1073\/pnas.87.7.2471","volume":"87","year":"1990","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"36","key":"157","doi-asserted-by":"crossref","first-page":"19827","DOI":"10.1016\/S0021-9258(19)77710-2","volume":"263","year":"1988","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"158","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0049-3848(84)90173-7","volume":"33","year":"1984","journal-title":"Thrombosis Research"},{"issue":"33","key":"159","doi-asserted-by":"crossref","first-page":"16157","DOI":"10.1016\/S0021-9258(18)47710-1","volume":"262","year":"1987","journal-title":"The Journal of Biological Chemistry"},{"issue":"14","key":"160","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1093\/nar\/18.14.4255","volume":"18","year":"1990","journal-title":"Nucleic Acids Research"},{"key":"161","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(83)90059-4"},{"issue":"6","key":"162","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0041-0101(83)90068-5","volume":"21","year":"1983","journal-title":"Toxicon"},{"issue":"3\u20136","key":"163","first-page":"183","volume":"31","year":"2001","journal-title":"Haemostasis"},{"key":"164","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1997.3821"},{"issue":"2","key":"165","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/bjc.1995.54","volume":"71","year":"1995","journal-title":"British Journal of Cancer"},{"key":"166","doi-asserted-by":"publisher","DOI":"10.1016\/0959-8049(95)00648-6"},{"issue":"9","key":"167","first-page":"2020","volume":"63","year":"2003","journal-title":"Cancer Research"},{"issue":"1","key":"168","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0014-4827(88)90346-1","volume":"179","year":"1988","journal-title":"Experimental Cell Research"},{"issue":"4-5","key":"169","first-page":"227","volume":"14","year":"2003","journal-title":"Oncology Research"},{"issue":"2","key":"170","first-page":"256","volume":"123","year":"1994","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"171","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(91)90449-5"},{"issue":"1","key":"172","first-page":"11","volume":"35","year":"1995","journal-title":"Biochemistry and Molecular Biology International"},{"issue":"6 b","key":"173","first-page":"4227","volume":"20","year":"2000","journal-title":"Anticancer Research"},{"key":"174","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000163426.25227.56"},{"key":"175","doi-asserted-by":"publisher","DOI":"10.1023\/B:AGEN.0000021396.47009.b0"},{"issue":"3","key":"176","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1023\/A:1009059210733","volume":"3","year":"1999","journal-title":"Angiogenesis"},{"issue":"4","key":"177","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1158\/1535-7163.499.3.4","volume":"3","year":"2004","journal-title":"Molecular Cancer Therapeutics"},{"issue":"2","key":"178","first-page":"109","volume":"46","year":"2005","journal-title":"Romanian Journal of Morphology and Embryology"},{"issue":"3","key":"179","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1620\/tjem.191.145","volume":"191","year":"2000","journal-title":"Tohoku Journal of Experimental Medicine"},{"issue":"3\u20136","key":"180","first-page":"192","volume":"31","year":"2001","journal-title":"Haemostasis"},{"key":"181","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3130"},{"key":"182","doi-asserted-by":"publisher","DOI":"10.1211\/0022357022160"},{"key":"183","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cgt.7700924"},{"key":"184","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-008-0358-y"},{"key":"185","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(00)01178-0"},{"key":"186","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.10.023"},{"key":"187","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.09.002"},{"key":"188","doi-asserted-by":"publisher","DOI":"10.1007\/BF01612672"},{"issue":"3","key":"189","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/0304-4165(67)90009-8","volume":"136","year":"1967","journal-title":"Biochimica et Biophysica Acta"},{"key":"190","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(98)00010-2"},{"issue":"4","key":"191","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.biologicals.2009.01.010","volume":"37","year":"2009","journal-title":"Biologicals"},{"issue":"6","key":"192","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/14786410701592679","volume":"22","year":"2008","journal-title":"Natural Product Research"},{"issue":"13","key":"193","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.lfs.2006.12.024","volume":"80","year":"2007","journal-title":"Life Sciences"},{"issue":"7","key":"194","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.bbagen.2011.04.003","volume":"1810","year":"2011","journal-title":"Biochimica et Biophysica Acta"},{"issue":"1","key":"195","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1590\/S1678-91992012000100004","volume":"18","year":"2012","journal-title":"Journal of Venomous Animals and Toxins including Tropical Diseases"},{"issue":"4","key":"196","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.toxicon.2006.01.006","volume":"47","year":"2006","journal-title":"Toxicon"},{"issue":"1","key":"197","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.toxicon.2011.05.013","volume":"58","year":"2011","journal-title":"Toxicon"},{"issue":"6","key":"198","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/abbs\/36.6.425","volume":"36","year":"2004","journal-title":"Acta Biochimica et Biophysica Sinica"},{"issue":"7","key":"199","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0945-053X(02)00068-9","volume":"21","year":"2002","journal-title":"Matrix Biology"},{"issue":"32","key":"200","doi-asserted-by":"crossref","first-page":"9859","DOI":"10.1021\/bi000428a","volume":"39","year":"2000","journal-title":"Biochemistry"},{"issue":"5","key":"201","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3892\/or.2013.2693","volume":"30","year":"2013","journal-title":"Oncology Reports"},{"issue":"5","key":"202","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/CAD.0b013e32835f258d","volume":"24","year":"2013","journal-title":"Anticancer Drugs"},{"issue":"1","key":"203","first-page":"52","volume":"32","year":"2013","journal-title":"Biology"},{"issue":"1","key":"204","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s10616-013-9540-z","volume":"66","year":"2014","journal-title":"Cytotechnology"},{"issue":"3","key":"205","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1159\/000341446","volume":"30","year":"2012","journal-title":"Cellular Physiology and Biochemistry"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/203639.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/203639.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/203639.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T17:13:06Z","timestamp":1746119586000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/203639\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":204,"alternative-id":["203639","203639"],"URL":"https:\/\/doi.org\/10.1155\/2014\/203639","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}