{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:12:42Z","timestamp":1780085562579,"version":"3.54.0"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["ID527502"],"award-info":[{"award-number":["ID527502"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>ATP is an important mediator of urgency in women with detrusor overactivity (DO). In order to understand how different degrees of bladder stretch elicited ATP release in DO patients compared with controls, sequential aliquots were collected during cystometry and ATP release was measured at each degree of bladder filling, in female patients with DO and controls. In both DO and control groups, ATP release was induced during bladder filling, suggesting that stretch stimulated further ATP release. However, the luminal ATP concentrations were already high at early filling stage (200\u2009mL), which was even greater than those at the later filling stages (400\u2009mL and maximum cystometric capacity, MCC), indicating that a substantial ATP release has been induced during early filling (200\u2009mL) in both DO and controls. In DO, ATP release at 200\u2009mL was significantly higher in those with low first desire to void (FDV) (\u2264200\u2009mL) than in those with higher FDV (&gt;200\u2009mL); this may suggest that ATP release at early stretch may play an important role in urgency (early sensation) in DO. ATP concentrations remained unchanged after voiding, suggesting that voiding did not further induce ATP release into intraluminal fluid.<\/jats:p>","DOI":"10.1155\/2014\/204604","type":"journal-article","created":{"date-parts":[[2014,5,27]],"date-time":"2014-05-27T22:53:22Z","timestamp":1401231202000},"page":"1-6","source":"Crossref","is-referenced-by-count":23,"title":["ATP during Early Bladder Stretch Is Important for Urgency in Detrusor Overactivity Patients"],"prefix":"10.1155","volume":"2014","author":[{"given":"Y.","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Urogynaecology, St George Hospital, University of New South Wales, Level 1, W.R. 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