{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:29:12Z","timestamp":1790666952043,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut national de la sant\u00e9 et de la recherche m\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Virology"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Although there is currently no evidence of emerging strains of measles virus (MV) that can resist neutralization by the anti-MV antibodies present in vaccinees, certain mutations in circulating wt MV strains appear to reduce the efficacy of these antibodies. Moreover, it has been hypothesized that resistance to neutralization by such antibodies could allow MV to persist. In this study, we use a novel<jats:italic>in vitro<\/jats:italic>system to determine the molecular basis of MV\u2019s resistance to neutralization. We find that both wild-type and laboratory strain MV variants that escape neutralization by anti-MV polyclonal sera possess multiple mutations in their H, F, and M proteins. Cytometric analysis of cells expressing viral escape mutants possessing minimal mutations and their plasmid-expressed H, F, and M proteins indicates that immune resistance is due to particular mutations that can occur in any of these three proteins that affect at distance, rather than directly, the native conformation of the MV-H globular head and hence its epitopes. A high percentage of the escape mutants contain mutations found in cases of Subacute Sclerosing Panencephalitis (SSPE) and our results could potentially shed light on the pathogenesis of this rare fatal disease.<\/jats:p>","DOI":"10.1155\/2014\/205617","type":"journal-article","created":{"date-parts":[[2014,2,4]],"date-time":"2014-02-04T21:01:33Z","timestamp":1391547693000},"page":"1-18","source":"Crossref","is-referenced-by-count":23,"title":["Mutations in the H, F, or M Proteins Can Facilitate Resistance of Measles Virus to Neutralizing Human Anti-MV Sera"],"prefix":"10.1155","volume":"2014","author":[{"given":"Hasan","family":"Kweder","sequence":"first","affiliation":[{"name":"INSERM-U1111, 69007 Lyon, France"},{"name":"ENS-Lyon, 69007 Lyon, France"},{"name":"University of Lyon, UCB-Lyon1, 69007 Lyon, France"},{"name":"LabEx Ecofect, University of Lyon, 69007 Lyon, 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