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entorhinal cortex (EC) may affect the hippocampal network activity because of the heavy interconnection between them. However, the mechanism by which the EC affects the discharge patterns and the transmission mode of epileptiform discharges within the hippocampus needs further study. Here, multielectrode recording techniques were used to study the spatiotemporal characteristics of epileptiform discharges in adult mouse hippocampal slices and combined EC-hippocampal slices and determine whether and how the EC affects the hippocampal neuron discharge patterns. The results showed that low-Mg<jats:sup>2+<\/jats:sup>artificial cerebrospinal fluid induced interictal discharges in hippocampal slices, whereas, in combined EC-hippocampal slices the discharge pattern was alternated between interictal and ictal discharges, and ictal discharges initiated in the EC and propagated to the hippocampus. The pharmacological effect of the antiepileptic drug valproate (VPA) was tested. VPA reversibly suppressed the frequency of interictal discharges but did not change the initiation site and propagation speed, and it completely blocked ictal discharges. Our results suggested that EC was necessary for the hippocampal ictal discharges, and ictal discharges were more sensitive than interictal discharges in response to VPA.<\/jats:p>","DOI":"10.1155\/2014\/205912","type":"journal-article","created":{"date-parts":[[2014,3,3]],"date-time":"2014-03-03T16:00:44Z","timestamp":1393862444000},"page":"1-15","source":"Crossref","is-referenced-by-count":9,"title":["Effect of the Entorhinal Cortex on Ictal Discharges in Low-Mg<sup><b>2+<\/b><\/sup>-Induced Epileptic Hippocampal Slice Models"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ye-Jun","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, 1630 Dong-Fang Road, Shanghai 200127, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Wei","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Qing","family":"Gong","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Ji","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pu-Ming","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong-Chuan Road, Shanghai 200240, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin-Chi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong 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