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has one of the highest incidences of childhood leukemia worldwide and significantly higher mortality rates for this disease compared with other countries. One possible cause is the high prevalence of gene rearrangements associated with the etiology or with a poor prognosis of childhood acute lymphoblastic leukemia (ALL). The aims of this multicenter study were to determine the prevalence of the four most common gene rearrangements [<jats:italic>ETV6-RUNX1, TCF3-PBX1, BCR-ABL1<\/jats:italic>, and<jats:italic>MLL<\/jats:italic>rearrangements] and to explore their relationship with mortality rates during the first year of treatment in ALL children from Mexico City. Patients were recruited from eight public hospitals during 2010\u20132012. A total of 282 bone marrow samples were obtained at each child\u2019s diagnosis for screening by conventional and multiplex reverse transcription polymerase chain reaction to determine the gene rearrangements. Gene rearrangements were detected in 50 (17.7%) patients.<jats:italic>ETV6-RUNX1<\/jats:italic>was detected in 21 (7.4%) patients,<jats:italic>TCF3-PBX1<\/jats:italic>in 20 (7.1%) patients,<jats:italic>BCR-ABL1<\/jats:italic>in 5 (1.8%) patients, and<jats:italic>MLL<\/jats:italic>rearrangements in 4 (1.4%) patients. The earliest deaths occurred at months 1, 2, and 3 after diagnosis in patients with<jats:italic>MLL, ETV6-RUNX1<\/jats:italic>, and<jats:italic>BCR-ABL1<\/jats:italic>gene rearrangements, respectively. Gene rearrangements could be related to the aggressiveness of leukemia observed in Mexican children.<\/jats:p>","DOI":"10.1155\/2014\/210560","type":"journal-article","created":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T17:03:49Z","timestamp":1405616629000},"page":"1-8","source":"Crossref","is-referenced-by-count":33,"title":["Prevalence of Gene Rearrangements in Mexican Children with Acute Lymphoblastic Leukemia: A Population Study\u2014Report from the Mexican Interinstitutional Group for the Identification of the Causes of Childhood Leukemia"],"prefix":"10.1155","volume":"2014","author":[{"given":"Vilma Carolina","family":"Bekker-M\u00e9ndez","sequence":"first","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunolog\u00eda e Infectolog\u00eda, Hospital de Infectolog\u00eda \u201cDr. Daniel M\u00e9ndez Hern\u00e1ndez\u201d, \u201cLa Raza\u201d, Instituto Mexicano del Seguro Social (IMSS), Avenida Jacarandas Esquina Vallejo S\/N colonia La Raza, 02990 M\u00e9xico, DF, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Miranda-Peralta","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Hospital General de M\u00e9xico, Secretaria de Salud (SS), Eje 2A Sur (Dr. Balmis) 148, Col. 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