{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T21:05:28Z","timestamp":1761599128333},"reference-count":51,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"University of Medicine and Pharmacy T\u00eergu Mure\u015f","award":["19\/11.12.2013"],"award-info":[{"award-number":["19\/11.12.2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The genetic polymorphisms of X-ray repair cross complementing group 1 (<jats:italic>XRCC1<\/jats:italic>), X-ray repair cross complementing group 3 (<jats:italic>XRCC3<\/jats:italic>), and xeroderma pigmentosum complementation group D (<jats:italic>XPD<\/jats:italic>) repair genes may lead to genetic instability and leukemogenesis. The purpose of the study was to evaluate the association between<jats:italic>XRCC1<\/jats:italic>Arg399Gln, Arg280His and Arg194Trp,<jats:italic>XRCC3<\/jats:italic>Thr241Met, and<jats:italic>XPD<\/jats:italic>Lys751Gln polymorphisms and the risk of developing CML in Romanian patients. A total of 156 patients diagnosed with CML and 180 healthy controls were included in this study. We found no association between CML and<jats:italic>XRCC1<\/jats:italic>or<jats:italic>XRCC3<\/jats:italic>variant genotypes in any of the investigated cases. A significant difference was observed in the variant genotype frequencies of the<jats:italic>XPD<\/jats:italic>Lys751Gln polymorphism between the patients with CML and control group (for variant homozygous genotypes,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mtext>O<\/mml:mtext><mml:mtext>R<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.37<\/mml:mn><\/mml:math>; 95%<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mtext>C<\/mml:mtext><mml:mtext>I<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.20<\/mml:mn><\/mml:math>\u20134.67;<jats:italic>P<\/jats:italic>value\u2009=\u20090.016 and for combined heterozygous and variant homozygous genotypes,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mtext>O<\/mml:mtext><mml:mtext>R<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.72<\/mml:mn><\/mml:math>; 95%<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mtext>C<\/mml:mtext><mml:mtext>I<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.10<\/mml:mn><\/mml:math>\u20132.69;<jats:italic>P<\/jats:italic>value\u2009=\u20090.019). This was also observed when analyzing the variant 751Gln allele (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mtext>O<\/mml:mtext><mml:mtext>R<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.54<\/mml:mn><\/mml:math>; 95%<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mtext>C<\/mml:mtext><mml:mtext>I<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>1.13<\/mml:mn><\/mml:math>\u20132.11;<jats:italic>P<\/jats:italic>value\u2009=\u20090.008). Our results suggest that the<jats:italic>XPD<\/jats:italic>Lys751Gln variant genotype increases the risk of CML.<\/jats:p>","DOI":"10.1155\/2014\/213790","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T17:02:24Z","timestamp":1400173344000},"page":"1-9","source":"Crossref","is-referenced-by-count":19,"title":["Polymorphism of<i>XRCC1<\/i>,<i>XRCC3<\/i>, and<i>XPD<\/i>Genes and Risk of Chronic Myeloid Leukemia"],"prefix":"10.1155","volume":"2014","author":[{"given":"Claudia","family":"B\u0103nescu","sequence":"first","affiliation":[{"name":"Department of Medical Genetics, University of Medicine and Pharmacy Tirgu Mures, 38 Gh, Marinescu Street, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian P.","family":"Trifa","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smaranda","family":"Demian","sequence":"additional","affiliation":[{"name":"Hematology Clinic 1, University of Medicine and Pharmacy Tirgu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzsebeth","family":"Benedek Lazar","sequence":"additional","affiliation":[{"name":"Hematology Clinic 2, University of Medicine and Pharmacy Tirgu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delia","family":"Dima","sequence":"additional","affiliation":[{"name":"Department of Hematology, \u201cIon Chiricuta\u201d Cancer Institute, Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Duicu","sequence":"additional","affiliation":[{"name":"Pediatric Clinic, University of Medicine and Pharmacy Tirgu Mures, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minodora","family":"Dobreanu","sequence":"additional","affiliation":[{"name":"Laboratory Medicine, University of Medicine and Pharmacy Tirgu Mures, 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