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In this study, we investigated both effects of 15d-PGJ2 and its protection mechanism in concanavalin A- (ConA-) induced autoimmune hepatitis in mice.<jats:italic>Materials and Methods<\/jats:italic>. In vivo, Balb\/C mice were injected with ConA (25\u2009mg\/kg) to induce acute autoimmune hepatitis, and 15d-PGJ2 (10\u2009<jats:italic>\u03bc<\/jats:italic>g or 25\u2009<jats:italic>\u03bc<\/jats:italic>g) was administered 1\u2009h before the ConA injection. The histological grade, proinflammatory cytokine levels, and NF-<jats:italic>\u03ba<\/jats:italic>B and PPAR<jats:italic>\u03b3<\/jats:italic>activity were determined 6, 12, and 24\u2009h after the ConA injection. In vitro, LO2 cells and RAW264.7 cells were pretreated with 15d-PGJ2 (2\u2009<jats:italic>\u03bc<\/jats:italic>M) 1\u2009h before the stimulation with ConA (30\u2009<jats:italic>\u03bc<\/jats:italic>g\/mL). The NF-<jats:italic>\u03ba<\/jats:italic>B and PPAR<jats:italic>\u03b3<\/jats:italic>activity were determined 30\u2009min after the ConA administration.<jats:italic>Results<\/jats:italic>. Pretreatment with 15d-PGJ2 reduced the pathological effects of ConA-induced autoimmune hepatitis and significantly reduced the levels of cytokines after injection. 15d-PGJ2 activated PPAR<jats:italic>\u03b3<\/jats:italic>, blocked the degradation of I<jats:italic>\u03ba<\/jats:italic>B<jats:italic>\u03b1<\/jats:italic>, and inhibited the translocation of NF-<jats:italic>\u03ba<\/jats:italic>B into the nucleus.<jats:italic>Conclusion<\/jats:italic>. These results indicate that 15d-PGJ2 protects against ConA-induced autoimmune hepatitis by reducing proinflammatory cytokines. This reduction in inflammation may correlate with the activation of PPAR<jats:italic>\u03b3<\/jats:italic>and the reduction in NF-<jats:italic>\u03ba<\/jats:italic>B activity.<\/jats:p>","DOI":"10.1155\/2014\/215631","type":"journal-article","created":{"date-parts":[[2014,7,10]],"date-time":"2014-07-10T21:09:24Z","timestamp":1405026564000},"page":"1-10","source":"Crossref","is-referenced-by-count":14,"title":["15-Deoxy-<i>\u03b3<\/i>12,14-prostaglandin J2 Reduces Liver Impairment in a Model of ConA-Induced Acute Hepatic Inflammation by Activation of PPAR<i>\u03b3<\/i>and Reduction in NF-<i>\u03ba<\/i>B Activity"],"prefix":"10.1155","volume":"2014","author":[{"given":"Kan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Shanghai Tenth People\u2019s Hospital, Tongji University School of Medicine, Shanghai 200072, 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