{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T05:22:17Z","timestamp":1775625737937,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Thyroid Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Subtotal thyroidectomy (STT) was previously considered the gold standard in the surgical management of multinodular goitre despite its propensity for recurrence. Our aim was to assess whether prior STT or unilateral lobectomy was associated with increased reoperative morbidity.<jats:italic>Methods<\/jats:italic>. A retrospective analysis was conducted extracting data from our endocrine surgical database for the period from January 1991 to June 2006. Two patient groups were defined: Group 1 consisted of patients with previous unilateral thyroid lobectomy; Group 2 had undergone previous STT. Specific outcomes investigated were transient and permanent recurrent laryngeal nerve (RLN) injury and hypoparathyroidism.<jats:italic>Results<\/jats:italic>. 494 reoperative cases were performed which consisted of 259 patients with previous unilateral lobectomy (Group 1) and 235 patients with previous subtotal thyroidectomy (Group 2). A statistically significant increase relating to previous STT was demonstrated in both permanent RLN injury (0.77% versus 3.4%, RR 4.38,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.038<\/mml:mn><\/mml:math>) and permanent hypoparathyroidism (1.5% versus 5.1%, RR 3.14,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.041<\/mml:mn><\/mml:math>). Transient nerve injury and hypocalcaemia incidence was comparable.<jats:italic>Conclusions<\/jats:italic>. Reoperative surgery following subtotal thyroidectomy is associated with a significantly increased risk of permanent recurrent laryngeal nerve injury and hypoparathyroidism when compared with previous unilateral thyroidectomy. Subtotal thyroidectomy should therefore no longer be recommended in the management of multinodular goitre.<\/jats:p>","DOI":"10.1155\/2014\/231857","type":"journal-article","created":{"date-parts":[[2014,1,19]],"date-time":"2014-01-19T05:36:25Z","timestamp":1390109785000},"page":"1-6","source":"Crossref","is-referenced-by-count":17,"title":["The Morbidity of Reoperative Surgery for Recurrent Benign Nodular Goitre: Impact of Previous Unilateral Thyroid Lobectomy versus Subtotal Thyroidectomy"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1306-9643","authenticated-orcid":true,"given":"Navin","family":"Rudolph","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery, University Hospital of Poitiers, 86021 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Dominguez","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, University Hospital of Poitiers, 86021 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Beaulieu","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, University Hospital of Poitiers, 86021 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"De Wailly","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, University Hospital of Poitiers, 86021 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Louis","family":"Kraimps","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, University Hospital of Poitiers, 86021 Poitiers, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9808-1"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.50.723"},{"key":"3","series-title":"Springer Specialist Surgery Series","volume-title":"Technique of thyroidectomy","year":"2009"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0491-7"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20634"},{"issue":"7","key":"6","first-page":"674","volume":"64","year":"1998","journal-title":"The American Surgeon"},{"issue":"6","key":"28","first-page":"604","volume":"111","year":"1992","journal-title":"Surgery"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20062"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-007-0201-6"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900287"},{"issue":"4","key":"10","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF01655417","volume":"12","year":"1988","journal-title":"World Journal of Surgery"},{"issue":"10","key":"11","first-page":"725","volume":"161","year":"1995","journal-title":"European Journal of Surgery"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0002-9610(78)90259-3","volume":"136","year":"1978","journal-title":"The American Journal of Surgery"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4507"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0491-7"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70088-7"},{"issue":"3","key":"17","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/00000658-198209000-00016","volume":"196","year":"1982","journal-title":"Annals of Surgery"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1053\/otot.2002.36442"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1007\/s005950170002"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1007\/s002680020100"},{"issue":"4","key":"22","first-page":"417","volume":"82","year":"1997","journal-title":"International Surgery"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1080\/110241598750005840"},{"issue":"1","key":"24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/BF02303703","volume":"2","year":"1995","journal-title":"Annals of Surgical Oncology"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03897.x"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-1433.2004.03139.x"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(99)70088-7"},{"issue":"4","key":"33","first-page":"309","volume":"171","year":"1990","journal-title":"Surgery Gynecology and Obstetrics"},{"issue":"4","key":"34","first-page":"319","volume":"176","year":"1993","journal-title":"Surgery Gynecology and Obstetrics"},{"issue":"12","key":"35","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1001\/archsurg.134.12.1389","volume":"134","year":"1999","journal-title":"Archives of Surgery"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.50.723"},{"issue":"6","key":"39","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1097\/00000658-198712000-00016","volume":"206","year":"1987","journal-title":"Annals of Surgery"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-1433.2004.03139.x"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7607-x"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2009.02.005"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.070841"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1007\/s00104-002-0605-3"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6060(05)80115-1"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-008-9483-2"}],"container-title":["Journal of Thyroid Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2014\/231857.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2014\/231857.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jtr\/2014\/231857.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T02:18:00Z","timestamp":1498097880000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jtr\/2014\/231857\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":39,"alternative-id":["231857","231857"],"URL":"https:\/\/doi.org\/10.1155\/2014\/231857","relation":{},"ISSN":["2090-8067","2042-0072"],"issn-type":[{"value":"2090-8067","type":"print"},{"value":"2042-0072","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}