{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T23:54:06Z","timestamp":1774742046005,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>OxLDL\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>2GPI complexes have been implicated in the initiation and progression of atherosclerosis and associated with disease severity and adverse outcomes. We investigate the significance of anti-oxLDL\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>2GPI antibodies and oxLDL\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>2GPI complexes in patients with arterial and idiopathic venous disease. A cohort of 61 arterial disease patients, 32 idiopathic venous disease patients, and 53 healthy controls was studied. Because statins influence oxLDL\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>2GPI, these complexes were analyzed on subjects not taking statins. Arterial and venous groups expressed higher levels of IgG anti-oxLDL\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>2GPI antibodies than controls without any other significant clinical association. OxLDL\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>2GPI complexes were significantly elevated in arterial (0.69\u2009U\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>) and venous disease (0.54\u2009U\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.025<\/mml:mn><\/mml:math>) than controls (0.39\u2009U\/mL). Among arterial diseases, oxLDL\/<jats:italic>\u03b2<\/jats:italic>2GPI was 0.85\u2009U\/mL for carotid artery disease, 0.72\u2009U\/mL for peripheral artery disease, and 0.52\u2009U\/mL for abdominal aortic aneurysm. There was a significant association with male gender, age, hypertension, and history of thrombosis. Subjects with oxLDL\/<jats:italic>\u03b2<\/jats:italic>2GPI above the median (0.25\u2009U\/mL) were more likely to have arterial (OR 4.5,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.004<\/mml:mn><\/mml:math>) or venous disease (OR 4.1,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.008<\/mml:mn><\/mml:math>). Multivariate regression indicated that males (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.021<\/mml:mn><\/mml:math>), high cholesterol (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:math>), and carotid disease (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.023<\/mml:mn><\/mml:math>) were significant predictors of oxLDL\/<jats:italic>\u03b2<\/jats:italic>2GPI. The coexistence of oxLDL\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>2GPI in arterial and venous disease may suggest a common oxidative mechanism that independently predicts carotid artery disease.<\/jats:p>","DOI":"10.1155\/2014\/234316","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T21:34:19Z","timestamp":1414532059000},"page":"1-5","source":"Crossref","is-referenced-by-count":9,"title":["Proatherogenic Oxidized Low-Density Lipoprotein\/<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi mathvariant=\"bold-italic\">\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>2-Glycoprotein I Complexes in Arterial and Venous Disease"],"prefix":"10.1155","volume":"2014","author":[{"given":"Jeffrey S.","family":"Berger","sequence":"first","affiliation":[{"name":"Department of Medicine, Divisions of Cardiology and Hematology, New York University School of Medicine, New York, NY 10016, USA"},{"name":"Department of Surgery, Division of Vascular Surgery, New York University School of Medicine, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caron B.","family":"Rockman","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Vascular Surgery, New York University School of Medicine, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirk E.","family":"Guyer","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Indiana University, South Bend, IN 46634, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis R.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Medical Department, Corgenix, Inc., 11575 Main Street, No. 400, Broomfield, CO 80020, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.529297"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2006.05.001"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0022-2275(20)31631-X","volume":"42","year":"2001","journal-title":"Journal of Lipid Research"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M200329-JLR200"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1361.073"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2007.06.003"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2007.12.028"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP2FJUT2YZGITK"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP88WVRDRDFBAS"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1177\/1474651410388057"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2012.04.003"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa022157"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02058.x"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2007.02467.x"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.709204"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-07-0469"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.04.019"}],"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/234316.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/234316.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/2014\/234316.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T20:27:33Z","timestamp":1650486453000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jir\/2014\/234316\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":17,"alternative-id":["234316","234316"],"URL":"https:\/\/doi.org\/10.1155\/2014\/234316","relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}