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CNB-001, a novel pyrazole derivative of curcumin, has recently been reported to possess various neuroprotective properties. This study was designed to investigate the neuroprotective mechanism of CNB-001 in a subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) rodent model of PD. Administration of MPTP (30\u2009mg\/kg for four consecutive days) exacerbated oxidative stress and motor impairment and reduced tyrosine hydroxylase (TH), dopamine transporter, and vesicular monoamine transporter 2 (VMAT2) expressions. Moreover, MPTP induced ultrastructural changes such as distorted cristae and mitochondrial enlargement in substantia nigra and striatum region. Pretreatment with CNB-001 (24\u2009mg\/kg) not only ameliorated behavioral anomalies but also synergistically enhanced monoamine transporter expressions and cosseted mitochondria by virtue of its antioxidant action. These findings support the neuroprotective property of CNB-001 which may have strong therapeutic potential for treatment of PD.<\/jats:p>","DOI":"10.1155\/2014\/236182","type":"journal-article","created":{"date-parts":[[2014,6,17]],"date-time":"2014-06-17T21:02:06Z","timestamp":1403038926000},"page":"1-11","source":"Crossref","is-referenced-by-count":39,"title":["CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson\u2019s Disease"],"prefix":"10.1155","volume":"2014","author":[{"given":"Richard L.","family":"Jayaraj","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Periyar University, Salem, Tamilnadu 636011, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namasivayam","family":"Elangovan","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Periyar University, Salem, Tamilnadu 636011, 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