{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T16:06:22Z","timestamp":1704729982253},"reference-count":18,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Autoimmune Diseases"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Familial Mediterranean fever (FMF) is an auto-inflammatory disease characterized by attacks of fever and polyserositis. FMF is often associated with other autoimmune diseases such as rheumatoid arthritis, polyarteritis nodosa (PAN), and Behcet. Uveitis is an inflammatory process caused by underlying infectious and inflammatory disorders. This study investigates the probable relationship between idiopathic uveitis and FMF.<jats:italic>Methods<\/jats:italic>. Patients with idiopathic uveitis were analyzed for the 12 most common MEFV mutations (P369S, F479L, M680I(G\/C), M680I(G\/A), I692del, M694V, M694I, K695R, V726A, A744S, R761H, E148Q) by a reverse hybridization assay (FMF StripAssay,Vienna lab,Vienna, Austria).<jats:italic>Results<\/jats:italic>. 12 patients with idiopathic uveitis were enrolled in this study. 10 of them were female. The youngest patient was a 7-year-old child and the oldest was 57. The most common complaints of patients were blurred vision and then eye redness. One patient was heterozygous for R761H. Genetic analysis of the 12 most common MEFV mutations in the patients with idiopathic uveitis didnot have any positive results.<jats:italic>Conclusion<\/jats:italic>. According to the analysis of the 12 most common MEFV gene mutations, FMF is not an underlying cause of idiopathic uveitis. On the other hand, uveitis merely could not be the first presentation of FMF.<\/jats:p>","DOI":"10.1155\/2014\/238931","type":"journal-article","created":{"date-parts":[[2014,1,30]],"date-time":"2014-01-30T16:15:41Z","timestamp":1391098541000},"page":"1-3","source":"Crossref","is-referenced-by-count":4,"title":["Idiopathic Uveitis and Familial Mediterranean Fever: Is There Any Relationship?"],"prefix":"10.1155","volume":"2014","author":[{"given":"Farhad","family":"Salehzadeh","sequence":"first","affiliation":[{"name":"Pediatric Department, Ardabil University of Medical Sciences (ARUMS), Ardabil 56157, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ozra","family":"Yasrebi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ardabil University of Medical Sciences (ARUMS), Bouali Hospital, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Hosseini Khotbesara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ardabil University of Medical Sciences (ARUMS), Bouali Hospital, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Hosseini Khotbesara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Ardabil University of Medical Sciences (ARUMS), Bouali Hospital, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740510017931"},{"issue":"3","key":"2","first-page":"271","volume":"16","year":"2000","journal-title":"Human Mutation"},{"issue":"5","key":"3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/S0049-0172(00)80015-3","volume":"29","year":"2000","journal-title":"Seminars in Arthritis and Rheumatism"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-010-1383-8"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1089\/gtmb.2009.0087"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(02)00106-2"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.58471"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.58468"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3102"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2009.05.002"},{"issue":"1","key":"11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12348-011-0044-8","volume":"2","year":"2012","journal-title":"Journal of Ophthalmic Inflammation and Infection"},{"issue":"10","key":"12","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/S0161-6420(84)34177-X","volume":"91","year":"1984","journal-title":"Ophthalmology"},{"issue":"3","key":"13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0161-6420(96)30682-9","volume":"103","year":"1996","journal-title":"Ophthalmology"},{"issue":"3","key":"14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1177\/112067219600600313","volume":"6","year":"1996","journal-title":"European Journal of Ophthalmology"},{"issue":"3","key":"15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.3109\/09273949709116894","volume":"5","year":"1997","journal-title":"Ocular Immunology and Inflammation"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-011-1840-z"},{"issue":"4","key":"17","first-page":"318","volume":"10","year":"2008","journal-title":"Israel Medical Association Journal"},{"issue":"4","key":"18","first-page":"644","volume":"9","year":"1982","journal-title":"Journal of Rheumatology"}],"container-title":["Autoimmune Diseases"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2014\/238931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2014\/238931.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ad\/2014\/238931.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T00:49:33Z","timestamp":1565138973000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/ad\/2014\/238931\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":18,"alternative-id":["238931","238931"],"URL":"https:\/\/doi.org\/10.1155\/2014\/238931","relation":{},"ISSN":["2090-0422","2090-0430"],"issn-type":[{"value":"2090-0422","type":"print"},{"value":"2090-0430","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}