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To further characterize the\u03b3<\/mml:mi>\u03b4<\/mml:mi><\/mml:math>T-cell immune status in B-cell non-Hodgkin lymphoma (B-NHL), we investigated the distribution and clonality of TCR V\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>\/V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>repertoire in peripheral blood (PB), bone marrow (BM), and lymph node (LN) from patients with B-NHL. Four newly diagnosed B-NHL cases, including three with diffuse large B-cell lymphoma (DLBCL) and one with small lymphocytic lymphoma (SLL), were enrolled. The restrictive expression of TCR V\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>\/V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>subfamilies with different distribution patterns could be detected in PB, BM, or LN from all of four patients, and partial subfamily T cells showed clonal proliferation. At least one clonally expanded V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>subfamily member was found in PB from each patient. However, the expression pattern and clonality of TCR V\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>\/V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>changed in different immune organs and showed individual feature in different patients. The clonally expanded V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>5, V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>6, and V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>8 were detected only in PB but neither in BM nor LN while clonally expanded V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>2 and V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>3 could be detected in both PB and BM\/LN. In conclusion, the results provide a preliminary profile of distribution and clonality of TCR\u03b3<\/mml:mi>\/<\/mml:mo>\u03b4<\/mml:mi><\/mml:math>subfamilies T cells in PB, BM, and LN from B-NHL; similar clonally expanded V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>subfamily T cells in PB and BM may be related to the same B-cell lymphoma-associated antigens, while the different reactive clonally expanded V\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>\/V\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>T cells may be due to local immune response.<\/jats:p>","DOI":"10.1155\/2014\/241246","type":"journal-article","created":{"date-parts":[[2014,5,21]],"date-time":"2014-05-21T21:07:31Z","timestamp":1400706451000},"page":"1-6","source":"Crossref","is-referenced-by-count":21,"title":["The Feature of Distribution and Clonality of TCR\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>\/\u03b4<\/mml:mi><\/mml:mrow><\/mml:math>Subfamilies T Cells in Patients with B-Cell Non-Hodgkin Lymphoma"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-9249","authenticated-orcid":true,"given":"Liang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre of Oncology and Hematology, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510230, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Rheumatism and Immunology, First Affiliated Hospital, Jinan University, Guangzhou 510632, China"},{"name":"Institute of Hematology, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyan","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Hematology, Jinan University, Guangzhou 510632, 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