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Loss of cardiac dystrophin initially leads to changes in dystrophin-associated glycoproteins and subsequently triggers secondarily sarcolemmal disintegration, fibre necrosis, fibrosis, fatty tissue replacement, and interstitial inflammation. This results in progressive cardiac disease, which is the cause of death in a considerable number of patients afflicted with X-linked muscular dystrophy. In order to better define the molecular pathogenesis of this type of cardiomyopathy, several studies have applied mass spectrometry-based proteomics to determine proteome-wide alterations in dystrophinopathy-associated cardiomyopathy. Proteomic studies included both gel-based and label-free mass spectrometric surveys of dystrophin-deficient heart muscle from the established<jats:italic>mdx<\/jats:italic>animal model of dystrophinopathy. Comparative cardiac proteomics revealed novel changes in proteins associated with mitochondrial energy metabolism, glycolysis, signaling, iron binding, antibody response, fibre contraction, basal lamina stabilisation, and cytoskeletal organisation. This review summarizes the importance of studying cardiomyopathy within the field of muscular dystrophy research, outlines key features of the<jats:italic>mdx<\/jats:italic>heart and its suitability as a model system for studying cardiac pathogenesis, and discusses the impact of recent proteomic findings for exploring molecular and cellular aspects of cardiac abnormalities in inherited muscular dystrophies.<\/jats:p>","DOI":"10.1155\/2014\/246195","type":"journal-article","created":{"date-parts":[[2014,3,20]],"date-time":"2014-03-20T21:01:22Z","timestamp":1395349282000},"page":"1-15","source":"Crossref","is-referenced-by-count":19,"title":["Proteomic Profiling of the Dystrophin-Deficient<i>mdx<\/i>Phenocopy of Dystrophinopathy-Associated Cardiomyopathy"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8256-7665","authenticated-orcid":true,"given":"Ashling","family":"Holland","sequence":"first","affiliation":[{"name":"Department of Biology, National 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