{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:10:34Z","timestamp":1789783834226,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01NS042604"],"award-info":[{"award-number":["5R01NS042604"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Cysticercosis is an infection of tissues with the larval cysts of the cestode,<jats:italic>Taenia<\/jats:italic>\u2009\u2009<jats:italic>solium<\/jats:italic>. While live parasites elicit little or no inflammation, dying parasites initiate a granulomatous reaction presenting as painful muscle nodules or seizures when cysts are located in the brain. We previously showed in the<jats:italic>T. crassiceps<\/jats:italic>murine model of cysticercosis that substance P (SP), a neuropeptide, was detected in early granulomas and was responsible for promoting granuloma formation, while somatostatin (SOM), another neuropeptide and immunomodulatory hormone, was detected in late granulomas; SOM\u2019s contribution to granuloma formation was not examined. In the current studies, we used somatostatin knockout (SOM<jats:sup>\u2212\/\u2212<\/jats:sup>) mice to examine the hypothesis that SOM downmodulates granulomatous inflammation in cysticercosis, thereby promoting parasite growth. Our results demonstrated that parasite burden was reduced 5.9-fold in SOM<jats:sup>\u2212\/\u2212<\/jats:sup>mice compared to WT mice (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). This reduction in parasite burden in SOM<jats:sup>\u2212\/\u2212<\/jats:sup>mice was accompanied by a 95% increase in size of their granulomas (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>), which contained a 1.5-fold increase in levels of IFN-<jats:italic>\u03b3<\/jats:italic>and a 26-fold decrease in levels of IL-1<jats:italic>\u03b2<\/jats:italic>(<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>for both) compared to granulomas from WT mice. Thus, SOM regulates both parasite burden and granulomatous inflammation perhaps through modulating granuloma production of IFN-<jats:italic>\u03b3<\/jats:italic>and IL-1<jats:italic>\u03b2<\/jats:italic>.<\/jats:p><jats:p><jats:ext-link ext-link-type=\"Corrigendum\"\/><jats:bold>Corrigendum to \u201cSomatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis\u201d<\/jats:bold><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"dx.doi.org\/10.1155\/2015\/869648\"\/><\/jats:p>","DOI":"10.1155\/2014\/247182","type":"journal-article","created":{"date-parts":[[2014,7,9]],"date-time":"2014-07-09T21:02:06Z","timestamp":1404939726000},"page":"1-6","source":"Crossref","is-referenced-by-count":5,"title":["Somatostatin Negatively Regulates Parasite Burden and Granulomatous Responses in Cysticercosis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Mitra","family":"Khumbatta","sequence":"first","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahrom","family":"Firozgary","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David John","family":"Tweardy","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Weinstock","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Tufts Medical Center, 800 Washington Street, P.O. 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