{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:45:44Z","timestamp":1782233144900,"version":"3.54.5"},"reference-count":65,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Monoclonal B-cell lymphocytosis (MBL) is a premalignant condition characterized by the presence of less than 5000\/<jats:italic>\u03bc<\/jats:italic>L circulating clonal B cells in otherwise healthy individuals. Three subcategories have been identified according to the immunophenotypic features: CLL-like, CD5(+) atypical, and CD5(\u2212) MBL. CLL-like MBL is by far the most frequent and best studied category and further divided in low-count [LC] and high-count [HC] MBL, based on a cutoff value of 500\/<jats:italic>\u03bc<\/jats:italic>L clonal B cells. LC-MBL typically remains stable and probably does not represent a truly premalignant condition, but rather an age-related immune senescence. On the other hand, HC-MBL is closely related to CLL-Rai0, bearing similar immunogenetic profile, and is associated with an annual risk of progression to CLL requiring therapy at a rate of 1.1%. Currently there are no reproducible factors for evaluating the risk of progression to CLL. CD5(\u2212) MBL is characterized by an immunophenotype consistent with marginal zone origin and displays many similarities with marginal zone lymphomas (MZL), mainly the splenic MZL. The cutoff value of 5000\/<jats:italic>\u03bc<\/jats:italic>L clonal B cells cannot probably be applied in CD5(\u2212) MBL, requiring a new definition to describe those cases.<\/jats:p>","DOI":"10.1155\/2014\/258917","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T21:01:46Z","timestamp":1410469306000},"page":"1-11","source":"Crossref","is-referenced-by-count":16,"title":["New Insights into Monoclonal B-Cell Lymphocytosis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Christina","family":"Kalpadakis","sequence":"first","affiliation":[{"name":"Department of Haematology, University Hospital, University of Crete, P.O. BOX 1352, 71110 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerassimos A.","family":"Pangalis","sequence":"additional","affiliation":[{"name":"Department of Haematology, Athens Medical Center-Psychikon Branch, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotirios","family":"Sachanas","sequence":"additional","affiliation":[{"name":"Department of Haematology, Athens Medical Center-Psychikon Branch, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodoros P.","family":"Vassilakopoulos","sequence":"additional","affiliation":[{"name":"Department of Haematology, University of Athens, Laikon General Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stavroula","family":"Kyriakaki","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital, University of Crete, P.O. BOX 1352, 71110 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Korkolopoulou","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Koulieris","sequence":"additional","affiliation":[{"name":"Department of Haematology, Athens Medical Center-Psychikon Branch, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Moschogiannis","sequence":"additional","affiliation":[{"name":"Department of Haematology, Athens Medical Center-Psychikon Branch, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xanthi","family":"Yiakoumis","sequence":"additional","affiliation":[{"name":"Department of Haematology, Athens Medical Center-Psychikon Branch, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pantelis","family":"Tsirkinidis","sequence":"additional","affiliation":[{"name":"Department of Haematology, Athens Medical Center-Psychikon Branch, 11525 Athens, Greece"},{"name":"Department of Haematology, 401 Military Hospital, 11525 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Kyrtsonis","sequence":"additional","affiliation":[{"name":"1st Department of Propedeutics, University of Athens, Laikon General Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Levidou","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Athens, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen A.","family":"Papadaki","sequence":"additional","affiliation":[{"name":"Department of Haematology, University Hospital, University of Crete, P.O. BOX 1352, 71110 Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayiotis","family":"Panayiotidis","sequence":"additional","affiliation":[{"name":"1st Department of Propedeutics, University of Athens, Laikon General Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria K.","family":"Angelopoulou","sequence":"additional","affiliation":[{"name":"Department of Haematology, University of Athens, Laikon General Hospital, 11527 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"issue":"1","key":"1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1182\/blood.V64.1.244.244","volume":"64","year":"1984","journal-title":"Blood"},{"issue":"5","key":"2","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1111\/j.1600-0609.1989.tb00335.x","volume":"43","year":"1989","journal-title":"European Journal of Haematology"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-01-197368"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.2.635"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-09-3277"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.08.005"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.305"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05550.x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20174"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06870.x"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075290"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-176933"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-523704"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07861.x"},{"issue":"1","key":"13","first-page":"1","volume":"52","year":"2003","journal-title":"Cytometry B: Clinical Cytometry"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-03-0892"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-09-176149"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07711.x"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.20"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20533"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.287"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.192"},{"issue":"5","key":"21","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3324\/haematol.2013.098913","volume":"99","year":"2014","journal-title":"Haematologica"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1080\/10428190701321277"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.09010.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.2704"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc086211"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2007.11.030"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1159\/000333621"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.666542"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2009.1.430"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.187"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-05-357251"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-471698"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067751"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06867.x"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23214"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPPHSUQM8XBJH7"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2011.117"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20390"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-01-404681"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S0531-5565(99)00095-9"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-393694"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052808"},{"key":"45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07849.x"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20110921"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-373159"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-12-395673"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2013"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2012.069369"},{"issue":"5","key":"51","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/bjh.12800","volume":"165","year":"2014","journal-title":"British Journal of Haematology"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050995"},{"key":"53","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1182\/blood-2013-01-478222","volume":"122","year":"2013","journal-title":"Blood"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.098913"},{"issue":"4","key":"55","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/ajcp\/99.4.402","volume":"99","year":"1993","journal-title":"The American Journal of Clinical Pathology"},{"key":"56","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1182\/blood-2014-01-546739","volume":"123","year":"2014","journal-title":"Blood"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-03-276683"},{"key":"58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06862.x"},{"key":"59","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.b.20543"},{"key":"60","doi-asserted-by":"publisher","DOI":"10.1309\/WB56ET6AGM44TM5T"},{"issue":"2","key":"61","first-page":"109","volume":"95","year":"2010","journal-title":"Haematologica"},{"issue":"2","key":"62","first-page":"p392","volume":"96","year":"2011","journal-title":"Haematologica"},{"issue":"s1","key":"63","first-page":"p86","volume":"97","year":"2012","journal-title":"Haematologica"},{"issue":"6","key":"64","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1182\/blood.V95.6.1950","volume":"95","year":"2000","journal-title":"Blood"},{"issue":"8","key":"65","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1182\/blood-2013-07-515155","volume":"123","year":"2014","journal-title":"Blood"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/258917.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/258917.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/258917.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T12:13:36Z","timestamp":1717330416000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/258917\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":65,"alternative-id":["258917","258917"],"URL":"https:\/\/doi.org\/10.1155\/2014\/258917","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}