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Novel drug delivery systems have been used to reduce the side effect of drugs commonly used in the topical treatment of acne. Topical treatment of acne with active pharmaceutical ingredients (API) makes direct contact with the target site before entering the systemic circulation which reduces the systemic side effect of the parenteral or oral administration of drug. The objective of the present review is to discuss the conventional delivery systems available for acne, their drawbacks, and limitations. The advantages, disadvantages, and outcome of using various carrier-based delivery systems like liposomes, niosomes, solid lipid nanoparticles, and so forth, are explained. This paper emphasizes approaches to overcome the drawbacks and limitations associated with the conventional system and the advances and application that are poised to further enhance the efficacy of topical acne formulations, offering the possibility of simplified dosing regimen that may improve treatment outcomes using novel delivery system.<\/jats:p>","DOI":"10.1155\/2014\/276260","type":"journal-article","created":{"date-parts":[[2014,2,9]],"date-time":"2014-02-09T16:00:46Z","timestamp":1391961646000},"page":"1-14","source":"Crossref","is-referenced-by-count":59,"title":["Carrier-Based Drug Delivery System for Treatment of Acne"],"prefix":"10.1155","volume":"2014","author":[{"given":"Amber","family":"Vyas","sequence":"first","affiliation":[{"name":"University Institute of Pharmacy, Pandit Ravishankar Shukla University, Raipur 492 010, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avinesh","family":"Kumar 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