{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T03:11:31Z","timestamp":1769742691528,"version":"3.49.0"},"reference-count":26,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"IGA MH CR","award":["NT\/12287-5"],"award-info":[{"award-number":["NT\/12287-5"]}]},{"name":"IGA MH CR","award":["PRVOUK P37\/12"],"award-info":[{"award-number":["PRVOUK P37\/12"]}]},{"name":"IGA MH CR","award":["NT\/12287-5"],"award-info":[{"award-number":["NT\/12287-5"]}]},{"name":"IGA MH CR","award":["PRVOUK P37\/12"],"award-info":[{"award-number":["PRVOUK P37\/12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Diabetes Research"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Lipoprotein-associated phospholipase A<jats:sub>2<\/jats:sub>(Lp-PLA<jats:sub>2<\/jats:sub>) is extensively expressed by advanced atherosclerotic lesions and may play a role in plaque instability. We selected a group of elderly subjects that underwent transcatheter aortic valve implantation (TAVI) or balloon angioplasty (BA) and separated them into two groups, diabetic and nondiabetic, to compare the level of Lp-PLA<jats:sub>2<\/jats:sub>mass between them.<jats:italic>Methods<\/jats:italic>. 44 patients aged<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>79.6<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>5.6<\/mml:mn><\/mml:math>years with symptomatic severe aortic valve stenosis underwent TAVI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>35<\/mml:mn><\/mml:math>) or BA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>9<\/mml:mn><\/mml:math>). 21 subjects had confirmed type 2 diabetes mellitus. Lp-PLA<jats:sub>2<\/jats:sub>mass was measured using an enzyme-linked immunosorbent assay kit (USCN Life Science, China) before and 3 days after the procedure.<jats:italic>Results<\/jats:italic>. Lp-PLA<jats:sub>2<\/jats:sub>mass was significantly elevated in this population (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mn>1296<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>358<\/mml:mn><\/mml:math>\u2009ng\/mL before TAVI;<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mn>1413<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>268<\/mml:mn><\/mml:math>\u2009ng\/mL before BA) and further increased after TAVI (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mn>1604<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>437<\/mml:mn><\/mml:math>\u2009ng\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>01<\/mml:mn><\/mml:math>) or BA (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mn>1808<\/mml:mn><mml:mo>\u00b1<\/mml:mo><mml:mn>303<\/mml:mn><\/mml:math>\u2009ng\/mL,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0<\/mml:mn><mml:mo>.<\/mml:mo><mml:mn>01<\/mml:mn><\/mml:math>). Lp-PLA<jats:sub>2<\/jats:sub>mass was significantly increased on the diabetic group before these interventions.<jats:italic>Conclusion.<\/jats:italic>Lp-PLA<jats:sub>2<\/jats:sub>may be a novel biomarker for the presence of rupture-prone atherosclerotic lesions in elderly patients. Levels of Lp-PLA<jats:sub>2<\/jats:sub>in diabetic patients may accompany the higher amount of small dense LDL particles seen in these subjects.<\/jats:p>","DOI":"10.1155\/2014\/278063","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T21:01:48Z","timestamp":1397163708000},"page":"1-6","source":"Crossref","is-referenced-by-count":13,"title":["Lipoprotein-Associated Phospholipase A<sub><b>2<\/b><\/sub>Mass Level Is Increased in Elderly Subjects with Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2014","author":[{"given":"J.","family":"Fortunato","sequence":"first","affiliation":[{"name":"3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Kr\u00e1lov\u00e9, Medical Faculty, Charles University, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Bl\u00e1ha","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Kr\u00e1lov\u00e9, Medical Faculty, Charles University, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bis","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Kr\u00e1lov\u00e9, Medical Faculty, Charles University, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"\u0160t\u2019\u00e1sek","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Kr\u00e1lov\u00e9, Medical Faculty, Charles University, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Andr\u00fds","sequence":"additional","affiliation":[{"name":"Department of Immunology and Alergology, University Hospital Hradec Kr\u00e1lov\u00e9, Medical Faculty, Charles University, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Voj\u00e1\u010dek","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Cardioangiology, University Hospital Hradec Kr\u00e1lov\u00e9, Medical Faculty, Charles University, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Jura\u0161kov\u00e1","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine, Metabolism and Gerontology, University Hospital Hradec Kr\u00e1lov\u00e9, Medical Faculty, Charles University, 50005 Hradec Kr\u00e1lov\u00e9, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Sobotka","sequence":"additional","affiliation":[{"name":"3rd Department of Internal Medicine, Metabolism and 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