{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:55:33Z","timestamp":1788872133436,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG 891451"],"award-info":[{"award-number":["CMRPG 891451"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG 891452"],"award-info":[{"award-number":["CMRPG 891452"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG 891451"],"award-info":[{"award-number":["CMRPG 891451"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Medical Foundation","doi-asserted-by":"publisher","award":["CMRPG 891452"],"award-info":[{"award-number":["CMRPG 891452"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    This study aims to determine the effect of age-related cartilage turnover on the serum C-telopeptide of type II collagen (CTX-II) and osteocalcin (OC) levels in growing rabbits with and without surgically induced osteoarthritis. Twenty-four New Zealand male 3-month-old rabbits were randomized into three operated groups (\n                    <jats:italic>n<\/jats:italic>\n                    = 6 per group, with surgically induced osteroarthritis in the right knee; after blood sampling, the knees were harvested following euthanization at 2, 3, and 6 months after surgery) and a control group (\n                    <jats:italic>n<\/jats:italic>\n                    = 6, blood samples were obtained monthly between 3 and 15 months). Histomorphologically, the medial femoral condyles, particularly the central parts, harbored the most severe osteoarthritic changes among the operated rabbits. The serum levels of CTX-II and OC decreased in the controls from 3 to 11 months and then remained stable. No significant differences in the serum CTX-II and OC levels between the osteoarthritic rabbits and controls were observed. The osteoarthritic-to-normal ratios (ONRs, the ratios of serum CTX-II or OC levels in osteoarthritic rabbits to those of the controls at same ages) enabled an overall assessment of osteoarthritis and age-related cartilage turnover. Elevated CTX-II ONRs were observed in rabbits with mild to advanced osteoarthritis. However, the OC ONRs were unhelpful in assessing osteoarthritic growing rabbits.\n                  <\/jats:p>","DOI":"10.1155\/2014\/284784","type":"journal-article","created":{"date-parts":[[2014,3,9]],"date-time":"2014-03-09T05:19:21Z","timestamp":1394342361000},"page":"1-9","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Age-Related Cartilage Turnover on Serum C-Telopeptide of Collagen Type II and Osteocalcin Levels in Growing Rabbits with and without Surgically Induced Osteoarthritis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Chung-Cheng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Chang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Jen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-Sheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Hang","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yi","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheung-Fat","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3488"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-011-1142-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1148\/rg.311105084"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.10.029"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203631"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(03)00056-5"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2005.09.020"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1002\/art.10576"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203726"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2012.07.009"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32835a9381"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.08.019"},{"issue":"4","key":"13","first-page":"697","volume":"32","year":"2005","journal-title":"Journal of Rheumatology"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.11.007"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2005.040642"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200010000-00004"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199805000-00017"},{"issue":"6","key":"18","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.joca.2013.03.008","volume":"21","year":"2013","journal-title":"Osteoarthritis and Cartilage"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.897"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.4.332"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07736.x"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.10.017"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.01.004"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2010.07.007"},{"issue":"5","key":"25","doi-asserted-by":"crossref","first-page":"522","DOI":"10.3109\/17453677008991540","volume":"41","year":"1970","journal-title":"Acta Orthopaedica Scandinavica"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2005.07.014"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2007.04.017"},{"issue":"4","key":"28","first-page":"363","volume":"1","year":"2001","journal-title":"Journal of Musculoskeletal and Neuronal Interactions"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.03.002"},{"issue":"2","key":"30","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/jor.1100020210","volume":"2","year":"1984","journal-title":"Journal of Orthopaedic Research"},{"issue":"2","key":"31","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1186\/ar1152","volume":"6","year":"2004","journal-title":"Arthritis Research & Therapy"},{"issue":"1","key":"32","doi-asserted-by":"crossref","first-page":"R9","DOI":"10.1186\/ar2596","volume":"11","year":"2009","journal-title":"Arthritis Research & Therapy"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1159\/000074419"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.10.038"},{"issue":"2","key":"35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jor.1100040211","volume":"4","year":"1986","journal-title":"Journal of Orthopaedic Research"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/284784.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/284784.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/284784.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T05:17:16Z","timestamp":1498108636000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/284784\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":35,"alternative-id":["284784","284784"],"URL":"https:\/\/doi.org\/10.1155\/2014\/284784","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}