{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T22:32:38Z","timestamp":1780957958818,"version":"3.54.1"},"reference-count":51,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Analytical Methods in Chemistry"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Simple, rapid, and extractive spectrophotometric methods were developed for the determination of some fluoroquinolones antibiotics: gemifloxacin mesylate (GMF), moxifloxacin hydrochloride (MXF), and enrofloxacin (ENF) in pure forms and pharmaceutical formulations. These methods are based on the formation of ion-pair complexes between the basic drugs and acid dyes, namely, bromocresol green (BCG), bromocresol purple (BCP), bromophenol blue (BPB), bromothymol blue (BTB), and methyl orange (MO) in acidic buffer solutions. The formed complexes were extracted with chloroform and measured at 420, 408, 416, 415, and 422\u2009nm for BCG, BCP, BPB, BTB, and MO, respectively, for GMF; at 410, 415, 416, and 420 nm for BCP, BTB, BPB, and MO, respectively, for MXF; and at 419 and 414 nm for BCG and BTB, respectively, in case of ENF. The analytical parameters and their effects are investigated. Beer\u2019s law was obeyed in the ranges 1.0\u201330, 1.0\u201320, and 2.0\u201324\u2009<jats:italic>\u03bc<\/jats:italic>g mL<jats:sup>\u22121<\/jats:sup>for GMF, MXF, and ENF, respectively. The proposed methods have been applied successfully for the analysis of the studied drugs in pure forms and pharmaceutical formulations. Statistical comparison of the results with the reference methods showed excellent agreement and indicated no significant difference in accuracy and precision.<\/jats:p>","DOI":"10.1155\/2014\/286379","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T01:26:40Z","timestamp":1390440400000},"page":"1-16","source":"Crossref","is-referenced-by-count":15,"title":["Spectrophotometric Determination of Gemifloxacin Mesylate, Moxifloxacin Hydrochloride, and Enrofloxacin in Pharmaceutical Formulations Using Acid Dyes"],"prefix":"10.1155","volume":"2014","author":[{"given":"Ayman A.","family":"Gouda","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa S.","family":"Amin","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Benha University, Benha, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragaa","family":"El-Sheikh","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira G.","family":"Yousef","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"98","reference":[{"key":"1","year":"2001"},{"key":"2","series-title":"Royal Pharmaceutical Society","year":"2009"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2009.06.003"},{"issue":"10","key":"5","first-page":"245","volume":"2","year":"2012","journal-title":"International Research Journal of Pharmacy and Pharmacology"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2010.08.047"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2010.06.031"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.08.013"},{"issue":"4","key":"9","first-page":"708","volume":"57","year":"2010","journal-title":"Journal of the Chinese Chemical Society"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.08.124"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2004.06.006"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2006.07.037"},{"issue":"2","key":"13","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jpha.2012.10.005","volume":"3","year":"2013","journal-title":"Journal of Pharmaceutical Analysis"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2009.01.016"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1002\/dta.143"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2007.06.023"},{"issue":"3","key":"17","doi-asserted-by":"crossref","first-page":"719","DOI":"10.3844\/ajassp.2005.719.729","volume":"2","year":"2005","journal-title":"American Journal of Applied Sciences"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1007\/s10895-010-0759-1"},{"issue":"5","key":"19","first-page":"616","volume":"5","year":"2011","journal-title":"African Journal of Pharmacy and Pharmacology"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-011-0633-0"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2008.12.046"},{"issue":"3","key":"22","first-page":"442","volume":"1","year":"2011","journal-title":"Asian Journal of Biochemical and Pharmaceutical Research"},{"issue":"1","key":"23","first-page":"90","volume":"3","year":"2012","journal-title":"International Journal of Research in Pharmaceutical and Biomedical Sciences"},{"issue":"6","key":"24","first-page":"130","volume":"1","year":"2010","journal-title":"International Journal of Chemical and Analytical Science"},{"issue":"2","key":"25","first-page":"132","volume":"2","year":"2010","journal-title":"Pharma Science Monitor"},{"issue":"3","key":"26","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1155\/2008\/801545","volume":"5","year":"2008","journal-title":"E-Journal of Chemistry"},{"issue":"3","key":"27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1155\/2008\/827984","volume":"5","year":"2008","journal-title":"E-Journal of Chemistry"},{"issue":"8","key":"28","first-page":"6508","volume":"21","year":"2009","journal-title":"Asian Journal of Chemistry"},{"issue":"1","key":"29","first-page":"1","volume":"9","year":"2010","journal-title":"Analytical Chemistry"},{"issue":"4","key":"30","first-page":"222","volume":"1","year":"2010","journal-title":"International Journal of Pharma Sciences and Research"},{"issue":"1","key":"31","first-page":"159","volume":"3","year":"2010","journal-title":"Rasayan Journal of Chemistry"},{"issue":"2","key":"32","first-page":"1634","volume":"22","year":"2010","journal-title":"Asian Journal of Chemistry"},{"issue":"3","key":"33","first-page":"453","volume":"3","year":"2011","journal-title":"Der Pharmacia Lettre"},{"issue":"6","key":"34","first-page":"21","volume":"2","year":"2010","journal-title":"Journal of Global Pharma Technology"},{"issue":"10","key":"35","first-page":"654","volume":"42","year":"2005","journal-title":"Indian Drugs"},{"issue":"2","key":"36","first-page":"343","volume":"52","year":"2007","journal-title":"Canadian Journal of Analytical Sciences and Spectroscopy"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.saa.2006.11.023"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2009.10.002"},{"issue":"4","key":"39","first-page":"2593","volume":"22","year":"2010","journal-title":"Asian Journal of Chemistry"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.4137\/ACI.S8090"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-1425(03)00327-5"},{"issue":"3","key":"42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0039-9140(95)01380-T","volume":"42","year":"1995","journal-title":"Talanta"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00524-6"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(01)00591-X"},{"issue":"1","key":"45","first-page":"173","volume":"68","year":"2000","journal-title":"Scientia Pharmaceutica"},{"issue":"1","key":"46","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/00032719908542599","volume":"32","year":"1999","journal-title":"Analytical Letters"},{"issue":"1","key":"47","first-page":"143","volume":"38","year":"1995","journal-title":"Eastern Pharmacist"},{"key":"48","year":"1952"},{"key":"49","year":"1971"},{"key":"50","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1021\/i560126a015","volume":"16","year":"1944","journal-title":"Industrial and Engineering Chemistry, Analytical Edition"},{"key":"51","year":"2005"},{"key":"52","year":"2005"}],"container-title":["Journal of Analytical Methods in Chemistry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jamc\/2014\/286379.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jamc\/2014\/286379.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/jamc\/2014\/286379.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T02:30:59Z","timestamp":1498098659000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/jamc\/2014\/286379\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":51,"alternative-id":["286379","286379"],"URL":"https:\/\/doi.org\/10.1155\/2014\/286379","relation":{},"ISSN":["2090-8865","2090-8873"],"issn-type":[{"value":"2090-8865","type":"print"},{"value":"2090-8873","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}