{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:46:43Z","timestamp":1767167203854,"version":"build-2238731810"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["GACR 304\/12\/0259"],"award-info":[{"award-number":["GACR 304\/12\/0259"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001824","name":"Grantov\u00e1 Agentura Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["AV0Z 50110509"],"award-info":[{"award-number":["AV0Z 50110509"]}],"id":[{"id":"10.13039\/501100001824","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ASCR","award":["GACR 304\/12\/0259"],"award-info":[{"award-number":["GACR 304\/12\/0259"]}]},{"name":"ASCR","award":["AV0Z 50110509"],"award-info":[{"award-number":["AV0Z 50110509"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    The activation of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase Ca\n                    <jats:sup>2+<\/jats:sup>\n                    entry. Hypertension and ageing are associated with altered Ca\n                    <jats:sup>2+<\/jats:sup>\n                    handling including possible activation of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels. Our study was aimed to determine Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels contribution to norepinephrine-induced contraction during hypertension and ageing. Norepinephrine-induced concentration-response curves of femoral arteries from 6- and 12-month-old spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were recorded using wire myograph. Pretreatment with Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent Cl- channel inhibitor indanyloxyacetic acid 94 [R(+)-IAA-94](IAA) attenuated norepinephrine-induced contraction in all groups, but relatively more in WKY than SHR arteries. The attenuation of norepinephrine-induced contraction after Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels blockade was partially reduced in 12-month-old WKY rats, but substantially diminished in 12-month-old SHR. IAA effect was enhanced after NO synthase inhibition but decreased by ageing. In 20-month-old WKY rats norepinephrine-induced contraction was not affected by IAA but was almost abolished after cyclooxygenase inhibition by indomethacin or niflumic acid. In conclusion, contribution of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels to norepinephrine-induced contraction diminished with age, hypertension development, and\/or NO synthesis inhibition. Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -dependent Cl\n                    <jats:sup>\u2212<\/jats:sup>\n                    channels are important for maintenance of normal vascular tone while their inactivation\/closing might be a pathological mechanism.\n                  <\/jats:p>","DOI":"10.1155\/2014\/289361","type":"journal-article","created":{"date-parts":[[2014,2,23]],"date-time":"2014-02-23T16:03:04Z","timestamp":1393171384000},"page":"1-9","source":"Crossref","is-referenced-by-count":16,"title":["Contribution of Ca\n                    <sup>2+<\/sup>\n                    -Dependent Cl\n                    <sup>\u2212<\/sup>\n                    Channels to Norepinephrine-Induced Contraction of Femoral Artery Is Replaced by Increasing EDCF Contribution during Ageing"],"prefix":"10.1155","volume":"2014","author":[{"given":"Silvia","family":"Liskova","sequence":"first","affiliation":[{"name":"Institute of Physiology, Academy of Sciences of the 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