{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:20:40Z","timestamp":1765887640200,"version":"3.37.3"},"reference-count":34,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100005668","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa do Distrito Federal","doi-asserted-by":"publisher","award":["193.000.353\/2010"],"award-info":[{"award-number":["193.000.353\/2010"]}],"id":[{"id":"10.13039\/501100005668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To evaluate the added value of QuantiFERON TB-Gold in-Tube (QTF-GIT) over the tuberculin skin testing (TST) for detecting latent tuberculosis (TB) infection (LTBI) among patients with AIDS in a city with a low TB incidence rate (11.1\/100,000 inhabitants) and universal BCG coverage.<jats:italic>Methods<\/jats:italic>. Three hundred consecutive patients with AIDS in eight outpatient sexually transmitted disease public clinics in Brasilia were submitted to QFT-IT and TST between May 2011 and March 2013. A positive result of either test was considered to be LTBI.<jats:italic>Results<\/jats:italic>. Median CD4-cell count was 477.5\u2009cells\/mm<jats:sup>3<\/jats:sup>; 295 (98.3%) were using antiretroviral therapy. Eighteen patients (6%, 95% CI: 3.6%\u20139.3%) had LTBI, of whom 4 (1.3%, 95% CI: 0.04%\u20132.63%) had only a positive TST, 8 (2.7%, 95% CI: 0.8%\u20134.5%) had only a QFT-GIT positive test, and 6 (2%, 95% CI: 0.4%\u20133.6%) had positive results for both tests. This represents an 81.8% relative increase in LTBI detection when QFT-GIT is added to TST. The concordance between both tests was 96% (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>k<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn fontstyle=\"italic\">0.48<\/mml:mn><\/mml:math>).<jats:italic>Conclusions<\/jats:italic>. The QFT-GIT alone was more effective to detect LTBI than TST alone and had an 81% added value as an add-on sequential test in this population with mild immunosuppression. The cost-effectiveness of these strategies remains to be evaluated.<\/jats:p>","DOI":"10.1155\/2014\/294963","type":"journal-article","created":{"date-parts":[[2014,5,29]],"date-time":"2014-05-29T17:04:37Z","timestamp":1401383077000},"page":"1-7","source":"Crossref","is-referenced-by-count":6,"title":["Added Value of QuantiFERON TB-Gold in-Tube for Detecting Latent Tuberculosis Infection among Persons Living with HIV\/AIDS"],"prefix":"10.1155","volume":"2014","author":[{"given":"Josiane Maria Oliveira","family":"Souza","sequence":"first","affiliation":[{"name":"University of Brasilia (UnB), Campus Universit\u00e1rio Darcy Ribeiro, 70910-900 Bras\u00edlia, DF, Brazil"},{"name":"SHA, Conjunto 5 ch\u00e1cara 47, Quadra D, Arniqueiras, 71995-297 Taguatinga, DF, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4074-6101","authenticated-orcid":true,"given":"Maria do Socorro 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