{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:31:08Z","timestamp":1740169868586,"version":"3.37.3"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychiatry Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Introduction<\/jats:italic>. Cerebral blood flow has been well studied in patients with panic disorder, but only few studies analyzed the mechanisms underlying the onset of a panic attack. The aim of the present study was to monitor the cerebral hemodynamics modifications during a panic attack.<jats:italic>Materials and Methods<\/jats:italic>. 10 panic disorder patients with recent onset, fully drug na\u00efve, were compared to 13 patients with panic disorder with a previous history of treatment and to 14 controls. A continuous bilateral monitoring of mean flow velocities in right and left middle cerebral arteries was performed by transcranial Doppler. Clomipramine was chosen as challenge.<jats:italic>Results<\/jats:italic>. Eight out of 10 patients drug na\u00efve and 6 control subjects out of 13 had a full blown panic attack during the test, whereas none of the patients with a history of treatment panicked. The occurrence of a panic attack was accompanied by a rapid decrease of flow velocities in both right and left middle cerebral arteries.<jats:italic>Discussion<\/jats:italic>. The bilateral acute decrease of mean flow velocity during a panic attack suggests the vasoconstriction of the microcirculation of deep brain structures perfused by middle cerebral arteries and involved in the so-called \u201cfear circuitry,\u201d thus suggesting that cerebral homeostatic dysfunctions seem to have a key role in the onset of a panic attack.<\/jats:p>","DOI":"10.1155\/2014\/296862","type":"journal-article","created":{"date-parts":[[2014,3,16]],"date-time":"2014-03-16T17:01:06Z","timestamp":1394989266000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Brain Circulation during Panic Attack: A Transcranial Doppler Study with Clomipramine Challenge"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6537-5880","authenticated-orcid":true,"given":"Francesco","family":"Rotella","sequence":"first","affiliation":[{"name":"Psychiatry Unit, Careggi University Hospital, Largo Brambilla 3, 50100 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marinella","family":"Marinoni","sequence":"additional","affiliation":[{"name":"Neurology Unit, Careggi University Hospital, Largo Brambilla 3, 50100 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Lejeune","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Careggi University Hospital, Largo Brambilla 3, 50100 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana","family":"Alari","sequence":"additional","affiliation":[{"name":"Neurology Unit, Careggi University Hospital, Largo Brambilla 3, 50100 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Depinesi","sequence":"additional","affiliation":[{"name":"Psychiatry Unit, Careggi University Hospital, Largo Brambilla 3, 50100 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5022-0488","authenticated-orcid":true,"given":"Fiammetta","family":"Cosci","sequence":"additional","affiliation":[{"name":"Section of Psychology and Psychiatry, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Faravelli","sequence":"additional","affiliation":[{"name":"Section of Psychology and Psychiatry, Department of Health Sciences, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"261","volume":"3","year":"1990","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1176\/ajp.143.4.469","volume":"143","year":"1986","journal-title":"American Journal of Psychiatry"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200506210-00010"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(93)90004-W"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(03)00062-3"},{"issue":"18","key":"6","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1097\/00001756-200112210-00020","volume":"12","year":"2001","journal-title":"NeuroReport"},{"issue":"3","key":"7","first-page":"325","volume":"14","year":"2003","journal-title":"NeuroReport"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.08.004"},{"issue":"6","key":"9","first-page":"412","volume":"42","year":"1991","journal-title":"Canadian Association of Radiologists Journal"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/15622970701216673"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0540-2"},{"issue":"4","key":"12","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1176\/ajp.145.4.442","volume":"145","year":"1988","journal-title":"American Journal of Psychiatry"},{"issue":"549","key":"13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1192\/bjp.119.549.129","volume":"119","year":"1971","journal-title":"British Journal of Psychiatry"},{"issue":"8","key":"14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1001\/archpsyc.1984.01790190038004","volume":"41","year":"1984","journal-title":"Archives of General Psychiatry"},{"issue":"8","key":"15","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1176\/ajp.144.8.1080","volume":"144","year":"1987","journal-title":"American Journal of Psychiatry"},{"issue":"7","key":"16","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1176\/ajp.141.7.857","volume":"141","year":"1984","journal-title":"American Journal of Psychiatry"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90510-9"},{"issue":"2","key":"18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0165-1781(87)90001-1","volume":"20","year":"1987","journal-title":"Psychiatry Research"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(90)90121-K"},{"issue":"6","key":"20","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1176\/ajp.147.6.796","volume":"147","year":"1990","journal-title":"American Journal of Psychiatry"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2007.07.015"},{"issue":"4","key":"22","first-page":"301","volume":"50","year":"1995","journal-title":"Therapie"},{"issue":"7","key":"23","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1176\/ajp.149.7.962","volume":"149","year":"1992","journal-title":"American Journal of Psychiatry"},{"issue":"6","key":"24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1001\/archpsyc.1989.01810060031006","volume":"46","year":"1989","journal-title":"Archives of General Psychiatry"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0738-7"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.035"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(98)00348-5"},{"issue":"5-6","key":"28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0306-4530(93)90009-A","volume":"18","year":"1993","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"29","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00004850-198701000-00003","volume":"2","year":"1987","journal-title":"International Clinical Psychopharmacology"},{"issue":"3","key":"30","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1007\/BF00216062","volume":"96","year":"1988","journal-title":"Psychopharmacology"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(90)90428-5"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2004.01.001"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-200005000-00007"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199920030-00007"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199412000-00016"},{"issue":"1","key":"36","first-page":"147","volume":"151","year":"1994","journal-title":"American Journal of Psychiatry"},{"issue":"2","key":"37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1176\/jnp.1.2.219","volume":"1","year":"1989","journal-title":"The Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00156-W"},{"issue":"3","key":"39","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1210\/jcem-68-3-632","volume":"68","year":"1989","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"issue":"1","key":"40","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0014-2999(84)90673-3","volume":"106","year":"1984","journal-title":"European Journal of Pharmacology"},{"issue":"6","key":"41","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3171\/jns.1982.57.6.0769","volume":"57","year":"1982","journal-title":"Journal of Neurosurgery"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01115-X"},{"issue":"3","key":"43","first-page":"447","volume":"153","year":"1996","journal-title":"American Journal of Psychiatry"},{"issue":"3","key":"44","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1176\/ajp.154.3.378","volume":"154","year":"1997","journal-title":"American Journal of Psychiatry"},{"year":"1994","key":"45"},{"year":"1997","key":"46"},{"issue":"4","key":"47","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3109\/00048677609159523","volume":"10","year":"1976","journal-title":"Australian and New Zealand Journal of Psychiatry"},{"year":"1970","key":"48"},{"key":"49","first-page":"4","volume":"58","year":"1997","journal-title":"Journal of Clinical Psychiatry"},{"issue":"417","key":"50","first-page":"38","volume":"108","year":"2003","journal-title":"Acta Psychiatrica Scandinavica, Supplement"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(96)00178-3"},{"issue":"6","key":"52","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1001\/archpsyc.1989.01810060025005","volume":"46","year":"1989","journal-title":"Archives of General Psychiatry"},{"issue":"4","key":"53","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1001\/archpsyc.49.4.311","volume":"49","year":"1992","journal-title":"Archives of General Psychiatry"},{"issue":"2","key":"54","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0193-953X(18)30504-5","volume":"11","year":"1988","journal-title":"Psychiatric Clinics of North America"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)90619-X"},{"issue":"3","key":"56","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00006842-199405000-00002","volume":"56","year":"1994","journal-title":"Psychosomatic Medicine"},{"key":"57","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(00)00130-5"}],"container-title":["Psychiatry Journal"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/psychiatry\/2014\/296862.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/psychiatry\/2014\/296862.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/psychiatry\/2014\/296862.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T09:55:11Z","timestamp":1565258111000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/psychiatry\/2014\/296862\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":57,"alternative-id":["296862","296862"],"URL":"https:\/\/doi.org\/10.1155\/2014\/296862","relation":{},"ISSN":["2314-4327","2314-4335"],"issn-type":[{"type":"print","value":"2314-4327"},{"type":"electronic","value":"2314-4335"}],"subject":[],"published":{"date-parts":[[2014]]}}}