{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:16:27Z","timestamp":1792552587065,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Mild cognitive impairment (MCI) is regarded as a prodromal phase of late onset Alzheimer\u2019s disease (LOAD). It has been proposed that oxidative stress (OxS) might be implicated in the pathogenesis of LOAD. The aim of this study was to investigate whether a redox imbalance measured as serum level of hydroperoxides (i.e., by-products of lipid peroxidation) and\/or serum antioxidant capacity might be predictive of the clinical progression of MCI to LOAD. The levels of these two markers were measured in 111 patients with MCI (follow-up:<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mn>2.0<\/mml:mn><mml:mi>\u00a0<\/mml:mi><mml:mo>\u00b1<\/mml:mo><mml:mi>\u00a0<\/mml:mi><mml:mn>0.6<\/mml:mn><\/mml:math>years), 105 patients with LOAD, and 118 nondemented healthy controls. Multivariate analysis adjusted for potential confounding factors, including age, gender, smoking, and comorbidities, showed a significant increase (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>) in baseline levels of OxS in MCI and LOAD as compared to cognitive healthy controls. No differences in either of OxS markers were found by comparing MCI patients who converted (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mi>n<\/mml:mi><mml:mi>\u00a0<\/mml:mi><mml:mo>=<\/mml:mo><mml:mi>\u00a0<\/mml:mi><mml:mn>29<\/mml:mn><\/mml:math>) or not converted (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mi>n<\/mml:mi><mml:mi>\u00a0<\/mml:mi><mml:mo>=<\/mml:mo><mml:mi>\u00a0<\/mml:mi><mml:mn>82<\/mml:mn><\/mml:math>) to LOAD. Overall, these results suggest that systemic OxS might be a precocious feature of MCI and LOAD. However, the role of OxS as an early prognostic marker of progression to LOAD needs further investigations.<\/jats:p>","DOI":"10.1155\/2014\/309507","type":"journal-article","created":{"date-parts":[[2014,1,12]],"date-time":"2014-01-12T16:01:35Z","timestamp":1389542495000},"page":"1-7","source":"Crossref","is-referenced-by-count":47,"title":["Systemic Oxidative Stress and Conversion to Dementia of Elderly Patients with Mild Cognitive Impairment"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-6300","authenticated-orcid":true,"given":"Carlo","family":"Cervellati","sequence":"first","affiliation":[{"name":"Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arianna","family":"Romani","sequence":"additional","affiliation":[{"name":"Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Seripa","sequence":"additional","affiliation":[{"name":"Gerontology and Geriatric Research Laboratory, IRCCS Casa Sollievo Della Sofferenza, San Giovanni Rotondo, Viale Cappuccini 1, 71013 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Cremonini","sequence":"additional","affiliation":[{"name":"Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Bosi","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Magon","sequence":"additional","affiliation":[{"name":"Section of Internal Medicine, Gerontology, and Clinical Nutrition, Department of Medical Science, University of Ferrara, Via Savonarola 9, 44100 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo M.","family":"Bergamini","sequence":"additional","affiliation":[{"name":"Section of Medical Biochemistry, Molecular Biology and Genetics, Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8792-0947","authenticated-orcid":true,"given":"Giuseppe","family":"Valacchi","sequence":"additional","affiliation":[{"name":"Department of Life Sciences and Biotechnology, University of Ferrara, Via Borsari 46, 44121 Ferrara, Italy"},{"name":"Department of Food and Nutrition, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Pilotto","sequence":"additional","affiliation":[{"name":"Geriatrics Unit, Azienda ULSS 16 Padova, S. 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