{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T09:05:02Z","timestamp":1772269502045,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background and Aim<\/jats:italic>. Tripartite motif-containing 29 (TRIM29) is structurally a member of the tripartite motif family of proteins and is involved in diverse human cancers. However, its role in pancreatic cancer remains unclear.<jats:italic>Methods<\/jats:italic>. The expression pattern of TRIM29 in pancreatic ductal adenocarcinoma was assessed by immunocytochemistry. Multivariate logistic regression analysis was used to investigate the association between TRIM29 and clinical characteristics.<jats:italic>In vitro<\/jats:italic>analyses by scratch wound healing assay and invasion assays were performed using the pancreatic cancer cell lines.<jats:italic>Results<\/jats:italic>. Immunohistochemical analysis showed TRIM29 expression in pancreatic cancer tissues was significantly higher\u2009\u2009<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>n<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>186<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math>than that in matched adjacent nontumor tissues. TRIM29 protein expression was significantly correlated with lymph node metastasis<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.019<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:mrow><\/mml:math>. Patients with positive TRIM29 expression showed both shorter overall survival and shorter recurrence-free survival than those with negative TRIM29 expression. Multivariate analysis revealed that TRIM29 was an independent factor for pancreatic cancer over survival (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mtext>HR<\/mml:mtext><mml:mo>=<\/mml:mo><mml:mn>2.180<\/mml:mn><\/mml:mrow><\/mml:math>, 95% CI: 1.324\u20134.198,<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.011<\/mml:mn><\/mml:mrow><\/mml:math>).<jats:italic>In vitro,<\/jats:italic>TRIM29 knockdown resulted in inhibition of pancreatic cancer cell proliferation, migration, and invasion.<jats:italic>Conclusions<\/jats:italic>. Our results indicate that TRIM29 promotes tumor progression and may be a novel prognostic marker for pancreatic ductal adenocarcinoma.<\/jats:p>","DOI":"10.1155\/2014\/317817","type":"journal-article","created":{"date-parts":[[2014,4,22]],"date-time":"2014-04-22T17:06:22Z","timestamp":1398186382000},"page":"1-7","source":"Crossref","is-referenced-by-count":23,"title":["TRIM29 as a Novel Biomarker in Pancreatic Adenocarcinoma"],"prefix":"10.1155","volume":"2014","author":[{"given":"Hongli","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Biliary and Vascular Surgery, Shengjing Hospital of China Medical University, Heping District, Shenyang 110004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6148-1464","authenticated-orcid":true,"given":"Xianwei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Biliary and Vascular Surgery, Shengjing Hospital of China Medical University, Heping 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