{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:29:29Z","timestamp":1791347369565,"version":"4.3.1"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["269067"],"award-info":[{"award-number":["269067"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["T\u00c9T_09-1-2010-0009"],"award-info":[{"award-number":["T\u00c9T_09-1-2010-0009"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hungarian National Office for Research and Technology","award":["269067"],"award-info":[{"award-number":["269067"]}]},{"name":"Hungarian National Office for Research and Technology","award":["T\u00c9T_09-1-2010-0009"],"award-info":[{"award-number":["T\u00c9T_09-1-2010-0009"]}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"crossref","award":["269067"],"award-info":[{"award-number":["269067"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003825","name":"Hungarian Academy of Sciences","doi-asserted-by":"crossref","award":["T\u00c9T_09-1-2010-0009"],"award-info":[{"award-number":["T\u00c9T_09-1-2010-0009"]}],"id":[{"id":"10.13039\/501100003825","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    The increasing number of multidrug-resistant microbes now emerging necessitates the identification of novel antimicrobial agents. Plants produce a great variety of antimicrobial peptides including hundreds of small, nodule-specific cysteine-rich NCR peptides that, in the legume\n                    <jats:italic>Medicago truncatula<\/jats:italic>\n                    , govern the differentiation of endosymbiotic nitrogen fixing bacteria and,\n                    <jats:italic>in vitro<\/jats:italic>\n                    , can display potent antibacterial activities. In this study, the potential candidacidal activity of 19 NCR peptides was investigated. Cationic NCR peptides having an isoelectric point above 9 were efficient in killing\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    , one of the most common fungal pathogens of humans. None of the tested NCR peptides were toxic for immortalized human epithelial cells at concentrations that effectively killed the fungus; however, at higher concentrations, some of them inhibited the division of the cells. Furthermore, the cationic peptides successfully inhibited\n                    <jats:italic>C. albicans<\/jats:italic>\n                    induced human epithelial cell death in an\n                    <jats:italic>in vitro<\/jats:italic>\n                    coculture model. These results highlight the therapeutic potential of cationic NCR peptides in the treatment of candidiasis.\n                  <\/jats:p>","DOI":"10.1155\/2014\/320796","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T17:01:21Z","timestamp":1409245281000},"page":"1-9","source":"Crossref","is-referenced-by-count":40,"title":["Symbiotic Plant Peptides Eliminate\n                    <i>Candida albicans<\/i>\n                    Both\n                    <i>In Vitro<\/i>\n                    and in an Epithelial Infection Model and Inhibit the Proliferation of Immortalized Human Cells"],"prefix":"10.1155","volume":"2014","author":[{"given":"Lilla","family":"\u00d6rd\u00f6gh","sequence":"first","affiliation":[{"name":"Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari Korut 62, Szeged 6726, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"V\u00f6r\u00f6s","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari Korut 62, Szeged 6726, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Nagy","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari Korut 62, Szeged 6726, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9va","family":"Kondorosi","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari Korut 62, Szeged 6726, Hungary"},{"name":"Institut des Sciences du V\u00e9g\u00e9tal, CNRS, Batiment 23, avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4421-6554","authenticated-orcid":true,"given":"Attila","family":"Kereszt","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Biological Research Centre of the Hungarian Academy of Sciences, Temesvari Korut 62, Szeged 6726, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2711"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2005.00616.x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1086\/380796"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/010405-0"},{"issue":"2","key":"5","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/CMR.11.2.382","volume":"11","year":"1998","journal-title":"Clinical Microbiology 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