{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T21:54:09Z","timestamp":1755035649580,"version":"3.40.5"},"reference-count":38,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Several studies report that the<jats:italic>OPG<\/jats:italic>is an important candidate gene in the pathogenesis of osteoporosis. This study aimed to detect the potential association of<jats:italic>OPG<\/jats:italic>gene polymorphisms with osteoporosis in postmenopausal women. We recruited 928 subjects containing 463 with primary postmenopausal osteoporosis and 465 healthy volunteers as controls. The BMD of neck hip, lumbar spine (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:msub><mml:mrow><mml:mtext>L<\/mml:mtext><\/mml:mrow><mml:mrow><mml:mn>2<\/mml:mn><mml:mtext>\u2013<\/mml:mtext><mml:mn>4<\/mml:mn><\/mml:mrow><\/mml:msub><\/mml:mrow><\/mml:math>), and total hip were assessed by dual-energy X-ray absorptiometry (DEXA). Through the created restriction site-polymerase chain reaction (CRS-PCR), PCR-restriction fragment length polymorphism (PCR-RFLP), and DNA sequencing methods, the g.18873C&gt;T and g.27522G&gt;A have been investigated. As for g.18873C&gt;T, our data indicated that subjects with CC genotype have significantly higher BMD value than those of CT and TT genotypes (all<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>values &lt;\u20090.05). As for g.27522G&gt;A, the BMD values of subjects with GG genotype were significantly higher than those of GA and AA genotypes (all<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>P<\/mml:mi><\/mml:mrow><\/mml:math>values &lt;\u20090.05). Our findings suggest that the<jats:italic>OPG<\/jats:italic>g.18873C&gt;T and g.27522G&gt;A genetic polymorphisms are associated with the decreased risk for osteoporosis in Chinese postmenopausal women.<\/jats:p>","DOI":"10.1155\/2014\/320828","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T21:00:55Z","timestamp":1418677255000},"page":"1-5","source":"Crossref","is-referenced-by-count":4,"title":["Association Analysis between g.18873C&gt;T and g.27522G&gt;A Genetic Polymorphisms of<i>OPG<\/i>and Bone Mineral Density in Chinese Postmenopausal Women"],"prefix":"10.1155","volume":"2014","author":[{"given":"Fei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, The General Hospital of Beijing Military Area Command, No. 5 Nanmencang Road, Dongcheng District, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The General Hospital of Beijing Military Area Command, No. 5 Nanmencang Road, Dongcheng District, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The General Hospital of Beijing Military Area Command, No. 5 Nanmencang Road, Dongcheng District, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlin","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The General Hospital of Beijing Military Area Command, No. 5 Nanmencang Road, Dongcheng District, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianlin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, The General Hospital of Beijing Military Area Command, No. 5 Nanmencang Road, Dongcheng District, Beijing 100700, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/oxfordjournals.epirev.a036281","volume":"7","year":"1985","journal-title":"Epidemiologic Reviews"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606263142605"},{"issue":"8","key":"3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","volume":"9","year":"1994","journal-title":"Journal of Bone and Mineral 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