{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T01:45:22Z","timestamp":1767836722610,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Coinfection produced by dengue virus (DENV) and hepatitis C virus (HCV) is a serious problem of public health in Mexico, as they both circulate in tropical zones and may lead to masking or complicating symptoms. In this research, we detected active coinfected patients by HCV residing in the endemic city of M\u00e9rida, Yucat\u00e1n, Mexico, with positive diagnosis to dengue during the acute phase. We performed a retrospective analysis of 240 serum samples from dengue patients. The IgM-ELISA serological test was used for dengue diagnosis, as well as viral isolation to confirm infection. DENV and HCV were detected by RT-PCR. Thus, 31 (12.9%) samples showed DENV-HCV coinfection, but interestingly the highest frequency of coinfection cases was found in male patients presenting hemorrhagic dengue in 19\/31 (61.29%), with a predominance of 12\u2009:\u20097 in males. Firstly, coinfection of DENV-HCV in M\u00e9rida, Mexico, was detected in young dengue patients, between 11 and 20 years old (38.7%), followed by those between 21 and 30 years old (32%); only 16.13% were between 0 and 10 years of age. Diagnosis of HCV infection in patients with dengue is highly recommended in order to establish potential risk in clinical manifestations as well as dictate patients' special care.<\/jats:p>","DOI":"10.1155\/2014\/321286","type":"journal-article","created":{"date-parts":[[2014,5,19]],"date-time":"2014-05-19T01:13:56Z","timestamp":1400462036000},"page":"1-5","source":"Crossref","is-referenced-by-count":7,"title":["Detection of Hepatitis C Virus Coinfection in Patients with Dengue Diagnosis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Carlos","family":"Machain-Williams","sequence":"first","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales Dr. Hideyo Noguchi (Unidad Inal\u00e1mbrica), Universidad Aut\u00f3noma de Yucat\u00e1n, 97225 M\u00e9rida, YUC, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes","family":"Talavera-Aguilar","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales Dr. Hideyo Noguchi (Unidad Inal\u00e1mbrica), Universidad Aut\u00f3noma de Yucat\u00e1n, 97225 M\u00e9rida, YUC, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa Carmina","family":"Cetina-Trejo","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales Dr. Hideyo Noguchi (Unidad Inal\u00e1mbrica), Universidad Aut\u00f3noma de Yucat\u00e1n, 97225 M\u00e9rida, YUC, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaquelin","family":"Carrillo-Navarrete","sequence":"additional","affiliation":[{"name":"Laboratorio de Enfermedades Emergentes y Re-emergentes, Centro de Investigaciones Regionales Dr. Hideyo Noguchi (Unidad Itz\u00e1es), Universidad Aut\u00f3noma de Yucat\u00e1n, 97000 M\u00e9rida, YUC, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nubia","family":"Rivero-C\u00e1rdenas","sequence":"additional","affiliation":[{"name":"Laboratorio de Arbovirolog\u00eda, Centro de Investigaciones Regionales Dr. Hideyo Noguchi (Unidad Inal\u00e1mbrica), Universidad Aut\u00f3noma de Yucat\u00e1n, 97225 M\u00e9rida, YUC, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma. 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