{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:49:56Z","timestamp":1790884196869,"version":"4.1.0"},"reference-count":56,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Pharmacological Sciences"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective.<\/jats:italic>The objective of this study was to find out the possible antiulcer mechanism of action of<jats:italic>Eremomastax speciosa<\/jats:italic>.<jats:italic>Method.<\/jats:italic>Carbachol- and histamine-induced hypersecretion, associated with the pylorus ligation technique, were used in rats. Gastric mucosal ulceration, mucus production, pH, gastric volume, and acidity were measured.<jats:italic>Results.<\/jats:italic>Histamine and carbachol raised gastric acidity to 86.50 and 84.80\u2009mEq\/L, respectively, in the control rats, and the extracts (200\u2009mg\/kg) reduced gastric acidity to 34.60 and 39.00\u2009mEq\/L, respectively. Intraduodenal aqueous extract (400\u2009mg\/kg) in histamine- and carbachol-treated rats produced significant (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) decreases in acid secretion to 28.50 and 28.80\u2009mEq\/L, respectively, and 100 percent inhibition of gastric ulceration. Augmented histamine-induced gastric acid secretion (90.20\u2009mEq\/L) was significantly reduced to 52.60 and 27.50\u2009mEq\/L by the 200 and 400\u2009mg\/kg doses of the aqueous extract, respectively. The extract significantly reduced (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>) the volume of gastric secretion and significantly increased mucus production. The ulcer inhibition potential of the extract significantly dropped to 25\u201344% (oral extract) and to 29\u201337% (duodenal extract) in carbachol\/indomethacin-treated rats.<jats:italic>Conclusion.<\/jats:italic>The aqueous extract of<jats:italic>E. speciosa<\/jats:italic>has both cytoprotective and antisecretory effects. The antisecretory effect may involve a mechanism common to both cholinergic and histaminergic pathways.<\/jats:p>","DOI":"10.1155\/2014\/323470","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T06:07:15Z","timestamp":1393394835000},"page":"1-10","source":"Crossref","is-referenced-by-count":8,"title":["Antisecretory Action of the Extract of the Aerial Parts of<i>Eremomastax speciosa (Acanthaceae)<\/i>Occurs through Antihistaminic and Anticholinergic Pathways"],"prefix":"10.1155","volume":"2014","author":[{"given":"Amang","family":"Andr\u00e9 Perfusion","sequence":"first","affiliation":[{"name":"Department of Animal Biology & Physiology, Faculty of Science, P.O. Box 812, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon"},{"name":"Department of Biological Sciences, Faculty of Science, P.O. Box 46, University of Maroua, Maroua, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul V.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Animal Biology & Physiology, Faculty of Science, P.O. Box 812, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nkwengoua","family":"Ernestine","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Science, P.O. Box 812, University of Yaound\u00e9 I, Yaound\u00e9, Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nyasse","family":"Barth\u00e9lemy","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Science, P.O. 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