{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:22:37Z","timestamp":1790036557456,"version":"4.0.1"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,28]],"date-time":"2014-12-28T00:00:00Z","timestamp":1419724800000},"content-version":"vor","delay-in-days":361,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Natural Science Fund of Shanghai","award":["08ZR1417700"],"award-info":[{"award-number":["08ZR1417700"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:p>The study aimed at testing the hypothesis that tongxinluo capsule might exert its cardioprotective effect by preventing ventricular remodeling and improving coronary microvascular function in a rat model of doxorubicin\u2010induced dilated cardiomyopathy (DCM). Rats that survived DCM induction were randomly divided into three groups to be given 1.5 g\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup> (TXL\u2010H, <jats:italic>n<\/jats:italic> = 9) or 0.15 g\u00b7kg<jats:sup>\u22121<\/jats:sup>\u00b7day<jats:sup>\u22121<\/jats:sup> (TXL\u2010L, <jats:italic>n<\/jats:italic> = 10) of tongxinluo, or normal saline at the same volume (DCM\u2010C, <jats:italic>n<\/jats:italic> = 10) intragastrically. Age matched normal rats treated with normal saline were used as normal controls (NOR\u2010C, <jats:italic>n<\/jats:italic> = 9). After four weeks of treatment, the DCM\u2010C, TXL\u2010H, and TXL\u2010L groups exhibited significant cardiac dysfunction, left ventricular remodeling, and coronary microvascular dysfunction, compared with the NOR\u2010C rats. However, myocardial functional parameters were significantly improved and microvascular density (MVD) increased in the TXL\u2010H group compared with the DCM\u2010C group (all <jats:italic>P<\/jats:italic> &lt; 0.01). Left ventricular remodeling was prevented. There were close linear relationships between CVF and LVEF (<jats:italic>r<\/jats:italic> = \u22120.683, <jats:italic>P<\/jats:italic> &lt; 0.05), MVD and LVEF (<jats:italic>r<\/jats:italic> = 0.895, <jats:italic>P<\/jats:italic> &lt; 0.05), and MVD and CVF (<jats:italic>r<\/jats:italic> = \u22120.798, <jats:italic>P<\/jats:italic> &lt; 0.05). It was indicated that high\u2010dose tongxinluo effectively improved cardiac function in rat model of DCM.<\/jats:p>","DOI":"10.1155\/2014\/323870","type":"journal-article","created":{"date-parts":[[2014,12,28]],"date-time":"2014-12-28T21:01:06Z","timestamp":1419800466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Traditional Chinese Medicine Tongxinluo Improves Cardiac Function of Rats with Dilated Cardiomyopathy"],"prefix":"10.1155","volume":"2014","author":[{"given":"Fang-Fang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Hui","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Qi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu-Min","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,28]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.174287"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.962050"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2006.10.002"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-013-1894-1"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2459\/jcm.0b013e32832bba35"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.6_Suppl.S46"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm200004133421502"},{"key":"e_1_2_9_8_2","first-page":"S5","article-title":"Effect of the addition of a \u03b2-blocker on left ventricular remodeling and prognosis in patients with dilated cardiomyopathy treated with angiotensin-converting enzyme inhibitor","volume":"41","author":"Hamada M.","year":"2003","journal-title":"Journal of Cardiovascular Pharmacology"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(99)00042-X"},{"key":"e_1_2_9_10_2","first-page":"247","article-title":"New pathogenetic mechanisms in idiopathic dilated cardiomyopathy: pathophysiologic and prognostic role of coronary microvascular dysfunction","volume":"94","author":"Neglia D.","year":"2003","journal-title":"Recenti Progressi in Medicina"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.05.064"},{"key":"e_1_2_9_12_2","first-page":"151","article-title":"Coronary microvascular dysfunction and idiopathic dilated cardiomyopathy","volume":"57","author":"Neglia D.","year":"2005","journal-title":"Pharmacological Reports"},{"key":"e_1_2_9_13_2","article-title":"Prognostic role of coronary microvascular dysfunction in mild dilated cardiomyopathy","volume":"96","author":"Neglia D. 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