{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T12:36:49Z","timestamp":1774355809405,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T00:00:00Z","timestamp":1394582400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ISRN Pharmacology"],"published-print":{"date-parts":[[2014,3,12]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. Hydroalcoholic extract of leaves of<jats:italic>Mallotus oppositifolius<\/jats:italic>(MOE), a plant used for CNS conditions in Ghana, was investigated for acute antidepressant effects in the forced swimming (FST) and tail suspension tests (TST).<jats:italic>Results<\/jats:italic>. In both FST and TST, MOE (10, 30, and 100\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>) significantly decreased immobility periods and frequencies. A 3-day pretreatment with 200\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.p., para-chlorophenylalanine (PCPA), a tryptophan hydroxylase inhibitor, reversed the decline in immobility and the increase of swimming score induced by MOE in the modified FST. Pretreatment with reserpine alone (1\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>),<jats:italic>\u03b1<\/jats:italic>-methyldopa alone (400\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.p.), or a combination of both drugs failed to reverse the decline in immobility or the increase in swimming score caused by the extract in the modified FST. The extract potentiated the frequency of head twitch responses induced by 5-hydroxytryptamine. Pretreatment with<jats:sc>d<\/jats:sc>-serine (600\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.p.), glycine\/NMDA agonist, abolished the behavioural effects of MOE while<jats:sc>d<\/jats:sc>-cycloserine (2.5\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>, i.p.), a glycine\/NMDA partial agonist, potentiated it in both TST and modified FST.<jats:italic>Conclusion<\/jats:italic>. The extract exhibited antidepressant effects in mice which is mediated by enhancement of serotoninergic neurotransmission and inhibition of glycine\/NMDA receptor activation.<\/jats:p>","DOI":"10.1155\/2014\/324063","type":"journal-article","created":{"date-parts":[[2014,3,12]],"date-time":"2014-03-12T21:02:17Z","timestamp":1394658137000},"page":"1-12","source":"Crossref","is-referenced-by-count":12,"title":["Antidepressant Effects of<i>Mallotus oppositifolius<\/i>in Acute Murine Models"],"prefix":"10.1155","volume":"2014","author":[{"given":"Kennedy K. 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