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Literature suggests in fact that the employment of adaptive emotional regulation strategies (e.g., reappraisal) causes a reduction of stress-elicited emotions leading to physical disorders. Conversely, dysfunctional emotional regulation strategies and, in particular, rumination and emotion suppression appear to be influential in the pathogenesis of depression and physiological disease. More specifically, the evidence suggests that depression and rumination affect both cognitive (e.g., impaired ability to process negative information) and neurobiological mechanisms (e.g., hypothalamic pituitary adrenal axis overactivation and higher rates of cortisol production). Understanding the factors that govern the variety of health outcomes that different people experience following exposure to stress has important implications for the development of effective emotion-regulation interventional approaches (e.g., mindfulness-based therapy, emotion-focused therapy, and emotion regulation therapy).<\/jats:p>","DOI":"10.1155\/2014\/324374","type":"journal-article","created":{"date-parts":[[2014,6,22]],"date-time":"2014-06-22T21:01:52Z","timestamp":1403470912000},"page":"1-10","source":"Crossref","is-referenced-by-count":155,"title":["Emotional Regulation and Depression: A Potential Mediator between Heart and Mind"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3336-7920","authenticated-orcid":true,"given":"Angelo","family":"Compare","sequence":"first","affiliation":[{"name":"Department of Human and Social Sciences, University of Bergamo, Piazza S. 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