{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T10:46:42Z","timestamp":1753181202679,"version":"3.37.3"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. To describe a case of postoperative scleritis caused by a novel strain of<jats:italic>Nocardia<\/jats:italic>resistant to linezolid and trimethoprim-sulfamethoxazole (TMP-SMX).<jats:italic>Methods<\/jats:italic>. Case report of a patient with microbiologically proven scleritis due to<jats:italic>Nocardia asteroides<\/jats:italic>.<jats:italic>Results<\/jats:italic>. The patient presented with pain, redness, and nodules on the sclera three months following pterygium excision with mitomycin C and amniotic membrane placement. As no response was noted with empiric treatment for bacterial scleritis, debridement was performed. The cytopathology report showed gram positive filamentous bacteria. A presumptive diagnosis of Nocardia scleritis was made and therapy was initiated based on a literature review on treatments for<jats:italic>Nocardia<\/jats:italic>infections. Cultures returned growing<jats:italic>Nocardia asteroides<\/jats:italic>. Antibiotic sensitivity testing revealed resistance to linezolid and TMP-SMX which are the traditional drugs of choice for<jats:italic>Nocardia<\/jats:italic>. The patient was treated with amikacin and imipenem as well as extensive debridement with pedicle grafts. The patient\u2019s scleritis resolved with a good visual outcome.<jats:italic>Conclusions<\/jats:italic>. Cultures should be obtained in all cases of necrotizing scleritis in patients with a recent history of conjunctival surgery to rule out unusual organisms such as<jats:italic>Nocardia<\/jats:italic>. Although literature states that resistance to linezolid and TMP-SMX is rare in<jats:italic>Nocardia<\/jats:italic>, sensitivity testing can be useful in unresponsive cases.<\/jats:p>","DOI":"10.1155\/2014\/326957","type":"journal-article","created":{"date-parts":[[2014,10,27]],"date-time":"2014-10-27T17:02:45Z","timestamp":1414429365000},"page":"1-3","source":"Crossref","is-referenced-by-count":3,"title":["Scleritis Caused by<i>In Vitro<\/i>Linezolid-Resistant<i>Nocardia asteroides<\/i>"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-8271","authenticated-orcid":true,"given":"Andres","family":"Gonzalez","sequence":"first","affiliation":[{"name":"College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0284, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9852-4336","authenticated-orcid":true,"given":"Kaihan","family":"Fakhar","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0284, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-6819","authenticated-orcid":true,"given":"David","family":"Gubernick","sequence":"additional","affiliation":[{"name":"College of Medicine, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0284, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonal","family":"Tuli","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, University of Florida, 1600 SW Archer Road, Gainesville, FL 32610-0284, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s12348-011-0043-9"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1086\/657399"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1295-1297.2001"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciq255"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2011.0043"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318259c952"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S37809"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71811-2"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)77042-4"},{"issue":"3","key":"11","first-page":"150","volume":"22","year":"1991","journal-title":"Ophthalmic Surgery"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2010.10.037"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-199405000-00015"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.043"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2014\/326957.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2014\/326957.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/criopm\/2014\/326957.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,28]],"date-time":"2016-07-28T16:40:28Z","timestamp":1469724028000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/criopm\/2014\/326957\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":13,"alternative-id":["326957","326957"],"URL":"https:\/\/doi.org\/10.1155\/2014\/326957","relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"type":"print","value":"2090-6722"},{"type":"electronic","value":"2090-6730"}],"subject":[],"published":{"date-parts":[[2014]]}}}