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Promoter assay data revealed that four methylated CpG sites presenting in the \u22122615 to \u22122239 nt region cause significant downregulation of<jats:italic>OPN<\/jats:italic>promoter activity. These data suggested that methylation in the<jats:italic>OPN<\/jats:italic>promoter plays a crucial role in the regulation of<jats:italic>OPN<\/jats:italic>expression that we found in cloned pigs genome.<\/jats:p>","DOI":"10.1155\/2014\/327538","type":"journal-article","created":{"date-parts":[[2014,7,2]],"date-time":"2014-07-02T21:09:11Z","timestamp":1404335351000},"page":"1-16","source":"Crossref","is-referenced-by-count":7,"title":["Osteoponin Promoter Controlled by DNA Methylation: Aberrant Methylation in Cloned Porcine Genome"],"prefix":"10.1155","volume":"2014","author":[{"given":"Chih-Jie","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-An","family":"Tsou","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan"},{"name":"School of Medicine, College of Medicine, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Otolaryngology Head and Neck Surgery, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao-Ling","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Bioresources, Da-Yeh University, Changhwa 515, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Jin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Pharmacy, China Medical University, Taichung 40402, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinn-Chih","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winston T. 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