{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:24:51Z","timestamp":1772839491322,"version":"3.50.1"},"reference-count":43,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gastroenterology Research and Practice"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background and Objective<\/jats:italic>.<jats:italic>H. pylori<\/jats:italic>infection causes a chronic inflammation in the gastric mucosa. However, this local inflammation may result in extra-digestive conditions. Our aim is to investigate the relationship between<jats:italic>H. pylori<\/jats:italic>infection and osteoporosis in Japan.<jats:italic>Methods<\/jats:italic>. This cross-sectional study was conducted among outpatients at the Juntendo University Hospital between 2008 and 2014. Participants for patient profile,<jats:italic>H. pylori<\/jats:italic>infection status, comorbidity, internal medical therapies, lumbar dual-energy X-ray absorptiometry (DXA), and bone turnover marker were collected and upper gastrointestinal endoscopy for reflux esophagitis, hiatal hernia, peptic ulcer disease (PUD), and endoscopic gastric mucosal atrophy (EGA) was performed. The diagnosis of osteoporosis was performed in accordance with the Japanese criteria. We investigated risk factors of osteoporosis.<jats:italic>Results<\/jats:italic>. Of the eligible 200 study subjects, 41 cases were of osteoporosis. Bivariate analysis showed that age, being female, BMI, alcohol, smoking,<jats:italic>H. pylori<\/jats:italic>, bone-specific ALP, PUD, and EGA were related to osteoporosis. Multivariate analysis showed that age (OR 1.13; 95%CI 1.07\u20131.20), being female (OR 4.77; 95%CI 1.78\u201312.77), BMI (OR 0.79; 95%CI 0.68\u20130.92),<jats:italic>H. pylori<\/jats:italic>(OR 5.33; 95%CI 1.73\u201316.42), and PUD (OR 4.98; 95%CI 1.51\u201316.45) were related to osteoporosis.<jats:italic>Conclusions<\/jats:italic>.<jats:italic>H. pylori<\/jats:italic>infection may be a risk factor of osteoporosis in Japan.<\/jats:p>","DOI":"10.1155\/2014\/340765","type":"journal-article","created":{"date-parts":[[2014,6,12]],"date-time":"2014-06-12T22:24:38Z","timestamp":1402611878000},"page":"1-9","source":"Crossref","is-referenced-by-count":20,"title":["The Relationship between<i>H. pylori<\/i>Infection and Osteoporosis in Japan"],"prefix":"10.1155","volume":"2014","author":[{"given":"Daisuke","family":"Asaoka","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Nagahara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariko","family":"Hojo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Shimada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yoshizawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Osada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumio","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"98","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)92035-Z"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0889-8553(21)00265-X","volume":"22","year":"1993","journal-title":"Gastroenterology Clinics of North America"},{"issue":"3","key":"3","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S1590-8658(01)80711-8","volume":"33","year":"2001","journal-title":"Digestive and Liver Disease"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1210\/en.139.6.2659"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.3109\/00365520903434117"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-0970-6"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-007-0794-4"},{"issue":"9","key":"8","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/1529-0131(200109)44:9<1969::AID-ART342>3.0.CO;2-A","volume":"44","year":"2001","journal-title":"Arthritis and Rheumatism"},{"issue":"3","key":"9","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1046\/j.1523-5378.1998.08018.x","volume":"3","year":"1998","journal-title":"Helicobacter"},{"issue":"6962","key":"10","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1136\/bmj.309.6962.1119","volume":"309","year":"1994","journal-title":"British Medical Journal"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.04.049"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1007\/s007740170001"},{"key":"13","first-page":"87","volume":"3","year":"1969","journal-title":"Endoscopy"},{"key":"14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/hel.12110","volume":"19","year":"2014","journal-title":"Helicobacter"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyp276"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1210\/er.23.3.279"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1993.tb01666.x"},{"issue":"10","key":"18","first-page":"2111","volume":"55","year":"1995","journal-title":"Cancer Research"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70365-8"},{"issue":"4","key":"20","first-page":"290","volume":"31","year":"1999","journal-title":"Italian Journal of Gastroenterology and Hepatology"},{"issue":"7","key":"21","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1128\/JCM.35.7.1710-1714.1997","volume":"35","year":"1997","journal-title":"Journal of Clinical Microbiology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222375399"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1086\/381782"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06565.x"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007736"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.6.2244-2246.2002"},{"issue":"7","key":"27","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1128\/JCM.37.7.2274-2279.1999","volume":"37","year":"1999","journal-title":"Journal of Clinical Microbiology"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.130079797"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2651-4"},{"issue":"3","key":"30","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1590\/S0004-28032007000300016","volume":"44","year":"2007","journal-title":"Arquivos de Gastroenterologia"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1589\/jpts.23.61"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-008-0417-5"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9292-0"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-003-1459-3"},{"issue":"8","key":"35","first-page":"1353","volume":"45","year":"1999","journal-title":"Clinical Chemistry"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1001\/jama.296.24.2947"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.007"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.1007\/s00774-004-0538-7"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-004-1640-3"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-006-0253-4"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01437-3"},{"issue":"1","key":"42","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/jbmr.5650110106","volume":"11","year":"1996","journal-title":"Journal of Bone and Mineral Research"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1863-y"}],"container-title":["Gastroenterology Research and Practice"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2014\/340765.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2014\/340765.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/grp\/2014\/340765.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T18:07:06Z","timestamp":1716833226000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/grp\/2014\/340765\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":43,"alternative-id":["340765","340765"],"URL":"https:\/\/doi.org\/10.1155\/2014\/340765","relation":{},"ISSN":["1687-6121","1687-630X"],"issn-type":[{"value":"1687-6121","type":"print"},{"value":"1687-630X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}