{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,25]],"date-time":"2025-05-25T21:20:37Z","timestamp":1748208037801,"version":"3.37.3"},"reference-count":29,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004843","name":"Manipal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Oral mucositis is one of the most debilitating side effects in patient undergoing chemotherapy or chemoradiotherapy. Leaves of the plant<jats:italic>Solanum nigrum<\/jats:italic>are used in folklore medicine to treat oral ulcers in India. However, no pharmacological investigation has been carried out till date. Aqueous extract of<jats:italic>Solanum nigrum<\/jats:italic>leaves (AESN) was prepared and subjected to various phytochemical screening. HPLC analysis of the ethyl acetate fraction was carried out. The aqueous extract (100 and 200\u2009mg\/kg) was further evaluated for its protective effect on two rat models: (a) busulfan plus infrared radiation (chemoradiotherapy) induced oral mucositis and (b) methotrexate (chemotherapy) induced oral mucositis. Various parameters including body weight change, food intake, and mortality were measured. AESN showed protective effect in both models of oral mucositis; however, the higher dose was more effective in chemotherapy induced oral mucositis. A reduction in oral mucositis score<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>was observed in the treatment groups. Significant<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mo stretchy=\"false\">(<\/mml:mo><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><mml:mo stretchy=\"false\">)<\/mml:mo><\/mml:math>improvement in food intake was also observed in AESN treated groups. Aqueous extract of<jats:italic>Solanum nigrum<\/jats:italic>leaves has protective effect on chemotherapy and chemoradiotherapy induced oral mucositis in rats.<\/jats:p>","DOI":"10.1155\/2014\/345939","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T16:13:39Z","timestamp":1416500019000},"page":"1-10","source":"Crossref","is-referenced-by-count":16,"title":["Protective Effects of Aqueous Extract of<i>Solanum nigrum<\/i>Linn. Leaves in Rat Models of Oral Mucositis"],"prefix":"10.1155","volume":"2014","author":[{"given":"Alkesh","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhankar","family":"Biswas","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed Haneefa","family":"Shoja","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grandhi Venkata","family":"Ramalingayya","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Nandakumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, 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