{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:14:03Z","timestamp":1770740043125,"version":"3.49.0"},"reference-count":27,"publisher":"Hindawi Limited","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. No established chemotherapeutic regimen exists for the treatment of recurrent malignant gliomas (rMGs). Herein, we report the activity and safety results of the bevacizumab (B) plus fotemustine (FTM) combination for the treatment of rMGs.<jats:italic>Patients and Methods<\/jats:italic>. An induction phase consisted of B 10\u2009mg\/kg days 1, 15 plus FTM 65\u2009mg\/m<jats:sup>2<\/jats:sup>days 1, 8, and 15. Nonprogressive patients entered the maintenance phase with B 10\u2009mg\/kg plus FTM 75 mg\/m<jats:sup>2<\/jats:sup>every 3 weeks. The primary endpoint was response rate; secondary endpoints included safety, progression free survival (PFS), and overall survival (OS).<jats:italic>Results<\/jats:italic>. Twenty-six patients affected by recurrent MGs (50% glioblastoma) were enrolled. Eight partial responses (31%) were observed. Median PFS and OS were 4 (95% C.I.: 2.8\u20135.1) and 6 months (95% C.I.: 4.2\u20137.8), respectively. Responses were significantly associated with both improved PFS and OS (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.002<\/mml:mn><\/mml:math>and<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mi>P<\/mml:mi><mml:mo>=<\/mml:mo><mml:mn>0.001<\/mml:mn><\/mml:math>, resp.). Treatment adverse events were mostly mild to moderate in intensity. Bevacizumab-related adverse events included grade 3 venous thromboembolic event (8%), grade 2 epistaxis (4%), hypertension (8%), and gastrointestinal perforation (4%).<jats:italic>Conclusions<\/jats:italic>. Bevacizumab plus FTM showed activity and good tolerability in pretreated MGs. Further investigations are needed in order to verify the benefits deriving from the addition of B to a cytotoxic in this clinical setting of patients.<\/jats:p>","DOI":"10.1155\/2014\/351252","type":"journal-article","created":{"date-parts":[[2014,5,4]],"date-time":"2014-05-04T17:06:00Z","timestamp":1399223160000},"page":"1-7","source":"Crossref","is-referenced-by-count":10,"title":["Activity and Safety of Bevacizumab Plus Fotemustine for Recurrent Malignant Gliomas"],"prefix":"10.1155","volume":"2014","author":[{"given":"V.","family":"Vaccaro","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fabi","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vidiri","sequence":"additional","affiliation":[{"name":"Diagnostic Oncology Department, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Giannarelli","sequence":"additional","affiliation":[{"name":"Biostatistic Unit, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Metro","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Santa Maria della Misericordia Hospital, Azienda Ospedaliera di Perugia, Perugia, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Telera","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Vari","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Piludu","sequence":"additional","affiliation":[{"name":"Diagnostic Oncology Department, Regina Elena National Cancer Institute, Via Elio Chianesi 53, 00144 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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