{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:00:33Z","timestamp":1787320833134,"version":"build-2736575974"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . We investigated the association between the reduction in the estimated glomerular filtration rate (eGFR) and the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in Korean males.\n                    <jats:italic>Methods<\/jats:italic>\n                    . We enrolled 723 healthy Korean males. Serum creatinine concentration, serum electrophoresis, serum immunofixation, and the serum free light chain assay were performed. We calculated delta eGFR per year (\u0394eGFR\/yr). The prevalence of MGUS was compared based on the \u0394eGFR\/yr and age group.\n                    <jats:italic>Results<\/jats:italic>\n                    . Thirteen (1.8%) of 723 participants exhibited the monoclonal band on serum immunofixation. Prevalence of MGUS by age group was 0.00% (0\/172 for 40 years), 1.63% (6\/367 for 60 years), and 3.80% (7\/184 for &gt;60 years). The median decrease in \u0394eGFR\/yr was 5.3%. The prevalence of MGUS in participants in their 50s with &gt;5.3% decline in \u0394eGFR\/yr was significantly higher than those with &lt;5.3% decrease in \u0394eGFR\/yr (3.16% versus 0.00%;\n                    <mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                      <mml:mi>P<\/mml:mi>\n                      <mml:mo>=<\/mml:mo>\n                      <mml:mn>0.049<\/mml:mn>\n                    <\/mml:math>\n                    ). The prevalence of MGUS in participants in their 50s with &gt;5.3% decrease in \u0394eGFR\/yr was similar to that of healthy males in their 60s.\n                    <jats:italic>Conclusion<\/jats:italic>\n                    . Using the rate of reduction in \u0394eGFR\/yr in healthy Korean males who had their serum creatinine level checked regularly may increase the MGUS detection rate in clinical practice.\n                  <\/jats:p>","DOI":"10.1155\/2014\/356080","type":"journal-article","created":{"date-parts":[[2014,5,8]],"date-time":"2014-05-08T17:17:01Z","timestamp":1399569421000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Association between the Delta Estimated Glomerular Filtration Rate and the Prevalence of Monoclonal Gammopathy of Undetermined Significance in Korean Males"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3873-3117","authenticated-orcid":true,"given":"Tae-Dong","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3956-6397","authenticated-orcid":true,"given":"Woochang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sail","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won-Ki","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60482-5"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa054494"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.22095"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0337"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2010.05.001"},{"issue":"9","key":"6","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/clinchem\/48.9.1437","volume":"48","year":"2002","journal-title":"Clinical Chemistry"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-270140"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.4065\/82.12.1474"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-466011"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2009.00582.x"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2013.08.024"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp052790"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.4065\/84.8.685"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.013961"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3449"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2010.07.027"},{"issue":"1-2","key":"17","first-page":"53","volume":"57","year":"2011","journal-title":"Clinical Laboratory"},{"issue":"4","key":"18","first-page":"348","volume":"40","year":"2010","journal-title":"Annals of Clinical and Laboratory Science"},{"issue":"4","key":"19","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/clinchem\/47.4.673","volume":"47","year":"2001","journal-title":"Clinical Chemistry"}],"container-title":["BioMed Research International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/356080.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/356080.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/bmri\/2014\/356080.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T01:18:25Z","timestamp":1597799905000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/bmri\/2014\/356080\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":19,"alternative-id":["356080","356080"],"URL":"https:\/\/doi.org\/10.1155\/2014\/356080","relation":{},"ISSN":["2314-6133","2314-6141"],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}