{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T12:48:44Z","timestamp":1740142124718,"version":"3.37.3"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Scientific World Journal"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To elucidate the time course of tumor metabolism during the first 3 months after<jats:sup>90<\/jats:sup>Y-ibritumomab tiuxetan radioimmunotherapy (RIT) in patients with refractory malignant lymphoma.<jats:italic>Materials and Methods<\/jats:italic>. Seven patients with recurrent follicular lymphoma underwent FDG-PET imaging before and after 1-, 4-, and 12-week RIT with<jats:sup>90<\/jats:sup>Y-ibritumomab tiuxetan. Tumor metabolic activity on FDG-PET scans was assessed as the maximum standard uptake value (SUVmax).<jats:italic>Results<\/jats:italic>. Decrease in metabolism was detected 1 week after RIT. In the most decreased lesion, SUVmax decreased to 20% of the baseline value during the first week. Most lesions continued to decrease for up to 4 weeks. Some lesions showed increased metabolism from 4 to 12 weeks, while the level of FDG accumulations at 12 weeks was still lower than the baseline.<jats:italic>Conclusions<\/jats:italic>. Tumor response to RIT could be observed as early as 1 week after the administration of RIT. After tumor activity decreases, the metabolism may increase at least between 4 and 12 weeks. It suggests that the metabolic changes should be carefully evaluated during this period.<\/jats:p>","DOI":"10.1155\/2014\/368947","type":"journal-article","created":{"date-parts":[[2014,6,22]],"date-time":"2014-06-22T09:55:48Z","timestamp":1403430948000},"page":"1-6","source":"Crossref","is-referenced-by-count":2,"title":["Dynamic Metabolic Changes during the First 3 Months after<sup>90<\/sup>Y-Ibritumomab Tiuxetan Radioimmunotherapy"],"prefix":"10.1155","volume":"2014","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3325-8601","authenticated-orcid":true,"given":"Miwako","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Radiology, Graduate School of Medicine, The University of Tokyo, 3-1 Hongo 7-Chome, Bunkyo-ku, Tokyo 113-8655, 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