{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:56:18Z","timestamp":1780584978751,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts. Although a role for BDNF in periodontal regeneration has been suggested, a function for BDNF in periodontal disease has not yet been studied. The aim of this study was to analyze the BDNF levels in periodontal tissues of patients with chronic periodontitis (CP) and periodontally healthy controls (HC). All subjects were genotyped for the rs4923463 and rs6265<jats:italic>BDNF<\/jats:italic>polymorphisms. Periodontal tissues were collected for ELISA, myeloperoxidase (MPO), and microscopic analysis from 28 CP patients and 29 HC subjects. BDNF levels were increased in CP patients compared to HC subjects. A negative correlation was observed when analyzing concentration of BDNF and IL-10 in inflamed periodontium. No differences in frequencies of BDNF genotypes between CP and HC subjects were observed. However,<jats:italic>BDNF<\/jats:italic>genotype GG was associated with increased levels of BDNF, TNF-<jats:italic>\u03b1<\/jats:italic>, and CXCL10 in CP patients. In conclusion, BDNF seems to be associated with periodontal disease process, but the specific role of BDNF still needs to be clarified.<\/jats:p>","DOI":"10.1155\/2014\/373765","type":"journal-article","created":{"date-parts":[[2014,12,21]],"date-time":"2014-12-21T21:00:32Z","timestamp":1419195632000},"page":"1-7","source":"Crossref","is-referenced-by-count":17,"title":["Brain-Derived Neurotrophic Factor in Chronic Periodontitis"],"prefix":"10.1155","volume":"2014","author":[{"given":"J\u00f4ice Dias","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele Sirineu","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, School of Physical Education, Physical Therapy and Occupational Therapy, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mila Fernandes Moreira","family":"Madeira","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso Martins","family":"Queiroz-Junior","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle Gl\u00f3ria","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Biological Sciences Institute, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro Martins","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Immunology, Biological Sciences Institute, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eust\u00e1quio","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio L\u00facio","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Medicine, Federal University of Minas Gerais, Professor Alfredo Balena Avenue 110, 30130-100 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarc\u00edlia Aparecida da","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Pathology, School of Dentistry, Federal University of Minas Gerais, Antonio Carlos Avenue 6627, 31.270-901 Belo Horizonte, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700908"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600403"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101312"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2005.11.1618"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084845"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-008-0910-4"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1996.67.6.555"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/760837"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2010.11.002"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/650685"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.23.10984"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.5.865"},{"issue":"2","key":"14","first-page":"129","volume":"45","year":"2007","journal-title":"Rhinology"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-013-2943-5"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2010.11.022"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.111.107037"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2009.03.017"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30723"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.050401"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2249"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1997"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0348-04.2004"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2007.06.003"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/372423"},{"issue":"11","key":"17","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.147.11.3815","volume":"147","year":"1991","journal-title":"The Journal of Immunology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2012.05.014"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(01)00405-7"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2010.08.003"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0151oc"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24330"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/373765.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/373765.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/373765.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,30]],"date-time":"2023-07-30T20:57:00Z","timestamp":1690750620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/mi\/2014\/373765\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":31,"alternative-id":["373765","373765"],"URL":"https:\/\/doi.org\/10.1155\/2014\/373765","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}