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CA enzymes are implicated as targets of variable drug therapeutic classes and the discovery of selective, drug-like CA inhibitors is essential. Just two natural product polyamines, spermine and spermidine, have until now been investigated as CA inhibitors. In this study, five more complex natural product polyamines<jats:bold>1\u20135<\/jats:bold>, derived from either marine sponge or fungi, were considered for inhibition of six different human CA isozymes of interest in therapeutic drug development. All compounds share a simple polyamine core fragment, either spermine or spermidine, yet display substantially different structure activity relationships for CA inhibition. Notably, polyamines<jats:bold>1\u20135<\/jats:bold>were submicromolar inhibitors of the cancer drug target CA IX, this is more potent than either spermine or spermidine.<\/jats:p>","DOI":"10.1155\/2014\/374079","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T21:02:50Z","timestamp":1407272570000},"page":"1-6","source":"Crossref","is-referenced-by-count":18,"title":["Natural Product Polyamines That Inhibit Human Carbonic Anhydrases"],"prefix":"10.1155","volume":"2014","author":[{"given":"Rohan A.","family":"Davis","sequence":"first","affiliation":[{"name":"Eskitis Institute for Drug Discovery, Griffith University, Nathan, QLD 4111, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Vullo","sequence":"additional","affiliation":[{"name":"Polo Scientifico, Laboratorio di Chimica Bioinorganica, Rm. 188, Universit\u00e0 degli Studi di Firenze, Via della Lastruccia 3, Sesto Fiorentino, 50019 Florence, 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