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One of the great challenges in this regard is that AD is not just a scientific problem; it is associated with major psychosocial and ethical dilemmas and has a negative impact on national economies. The neurodegenerative process that occurs in AD involves a specific nervous cell dysfunction, which leads to neuronal death. Mutations in APP, PS1, and PS2 genes are causes for early onset AD. Several animal models have demonstrated that alterations in these proteins are able to induce oxidative damage, which in turn favors the development of AD. This paper provides a review of many, although not all, of the mutations present in patients with familial Alzheimer\u2019s disease and the association between some of these mutations with both oxidative damage and the development of the pathology.<\/jats:p>","DOI":"10.1155\/2014\/375968","type":"journal-article","created":{"date-parts":[[2014,1,14]],"date-time":"2014-01-14T21:02:00Z","timestamp":1389733320000},"page":"1-14","source":"Crossref","is-referenced-by-count":44,"title":["Early Onset Alzheimer\u2019s Disease and Oxidative Stress"],"prefix":"10.1155","volume":"2014","author":[{"given":"Marco Antonio","family":"Meraz-R\u00edos","sequence":"first","affiliation":[{"name":"Departamento de Biomedicina Molecular, Centro de Investigaci\u00f3n y de Estudios Avanzados del Instituto Polit\u00e9cnico Nacional, Instituto Polit\u00e9cnico Nacional 2508, 07360 Mexico City, 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