{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:50:26Z","timestamp":1781225426370,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Ministry of Science and Innovation of Spain","award":["PI10\/00479"],"award-info":[{"award-number":["PI10\/00479"]}]},{"name":"Ministry of Science and Innovation of Spain","award":["11\/2011"],"award-info":[{"award-number":["11\/2011"]}]},{"DOI":"10.13039\/100009469","name":"Catalan Society of Ophthalmology","doi-asserted-by":"crossref","award":["PI10\/00479"],"award-info":[{"award-number":["PI10\/00479"]}],"id":[{"id":"10.13039\/100009469","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009469","name":"Catalan Society of Ophthalmology","doi-asserted-by":"crossref","award":["11\/2011"],"award-info":[{"award-number":["11\/2011"]}],"id":[{"id":"10.13039\/100009469","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mediators of Inflammation"],"published-print":{"date-parts":[[2014]]},"abstract":"<jats:p>The aim of the present study was to determine the serum cytokine profile and levels of high sensitivity C-reactive protein (hsCRP) in patients with uveitis associated with Beh\u00e7et\u2019s disease (BD) and to compare them with those obtained from healthy control subjects. We determined the serum concentration of interferon-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>(IFN-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>), interleukin-1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>(IL-1<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\"><mml:mrow><mml:mi>\u03b2<\/mml:mi><\/mml:mrow><\/mml:math>), IL-12p70, IL-17A, tumor necrosis factor-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>(TNF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>), and hsCRP in 13 patients with active uveitis associated to BD, 24 inactive BD patients, and 20 controls. In a subgroup of 10 active patients, a second serum sample was obtained when the disease was inactive. Cytokine profiles and hsCRP levels were correlated with disease activity, severity, complications, and visual outcome. Levels of IFN-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>and TNF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>were significantly increased in patients with active uveitis associated to BD compared to controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). IFN-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>, TNF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M11\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>, and hsCRP were significantly higher during active uveitis associated to BD compared to inactive disease (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M12\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). Furthermore, IL-17A was significantly increased in patients with active BD without pharmacological treatment compared to controls (<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M13\"><mml:mi>P<\/mml:mi><mml:mo>&lt;<\/mml:mo><mml:mn>0.05<\/mml:mn><\/mml:math>). No significant correlations were found with specific cytokine profiles and disease severity, visual outcome, or complications. In summary, increased serum levels of IFN-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M14\"><mml:mrow><mml:mi>\u03b3<\/mml:mi><\/mml:mrow><\/mml:math>, TNF-<mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M15\"><mml:mrow><mml:mi>\u03b1<\/mml:mi><\/mml:mrow><\/mml:math>, IL-17A, and hsCRP were associated with active uveitis associated with BD and might serve as markers of disease activity.<\/jats:p>","DOI":"10.1155\/2014\/396204","type":"journal-article","created":{"date-parts":[[2014,6,8]],"date-time":"2014-06-08T17:00:25Z","timestamp":1402246825000},"page":"1-8","source":"Crossref","is-referenced-by-count":32,"title":["Proinflammatory Cytokines and C-Reactive Protein in Uveitis Associated with Beh\u00e7et\u2019s Disease"],"prefix":"10.1155","volume":"2014","author":[{"given":"Marina","family":"Mesquida","sequence":"first","affiliation":[{"name":"Institut Cl\u00ednic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"Molins","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain"},{"name":"Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Lloren\u00e7","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Sainz de la Maza","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Rheumatology Department, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Autoimmune Disease Department, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Ad\u00e1n","sequence":"additional","affiliation":[{"name":"Institut Cl\u00ednic d'Oftalmologia, Hospital Clinic de Barcelona, University of Barcelona, Sabino de Arana 1, 08028 Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.10.005"},{"issue":"3","key":"2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/ar757","volume":"5","year":"2003","journal-title":"Arthritis Research and Therapy"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2007.09.002"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2007.080432"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2007.123554"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/09273940903072443"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.158840"},{"key":"8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10792-013-9788-5","volume":"34","year":"2014","journal-title":"International Ophthalmol"},{"issue":"2","key":"9","first-page":"329","volume":"25","year":"1998","journal-title":"Journal of Rheumatology"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1080\/030097402320318387"},{"issue":"4","key":"11","first-page":"227","volume":"17","year":"2011","journal-title":"Medical Science Monitor"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-1390"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1186\/ar3824"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/ng.624"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1038\/ng.625"},{"issue":"8697","key":"16","first-page":"1078","volume":"335","year":"1990","journal-title":"Lancet"},{"issue":"2","key":"17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0002-9394(14)74235-7","volume":"103","year":"1987","journal-title":"The American Journal of Ophthalmology"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.03.057"},{"issue":"9","key":"19","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/bjo.77.9.584","volume":"77","year":"1993","journal-title":"The British Journal of Ophthalmology"},{"issue":"11","key":"20","first-page":"3480","volume":"41","year":"2000","journal-title":"Investigative Ophthalmology and Visual Science"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.03.022"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200101000-00004"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R400025200"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6722com"},{"issue":"12","key":"26","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/S1357-2725(98)00078-8","volume":"30","year":"1998","journal-title":"The International Journal of Biochemistry and Cell Biology"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.174359"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr226"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205378200"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000125527.41598.68"}],"container-title":["Mediators of Inflammation"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/396204.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/396204.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/mi\/2014\/396204.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T10:31:59Z","timestamp":1498127519000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.hindawi.com\/journals\/mi\/2014\/396204\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":30,"alternative-id":["396204","396204"],"URL":"https:\/\/doi.org\/10.1155\/2014\/396204","relation":{},"ISSN":["0962-9351","1466-1861"],"issn-type":[{"value":"0962-9351","type":"print"},{"value":"1466-1861","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}